1. Intraoperative validation of quantitative T2 mapping in patients with articular cartilage lesions of the knee 
S.T. Soellner, A. Goldmann, D. Muelheims, G.H. Welsch, M.L. Pachowsky 
Osteoarthritis and Cartilage 
Volume 25, Issue 11, Pages (November 2017)
DOI: /j.joca
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2. Fig. 1
A, The sagittal 3D PD-SPACE MR image (left) and the corresponding color-coded T2 map (right) show intact articular cartilage. Apparent are low T2 relaxation times and a clearly distinguishable zonal variation with a slight zonal increase of T2 values in the superficial layer. The ROIs used for image analysis are enclosed in frames. B, Arthroscopy here confirms a completely intact cartilage surface (ICRS score 0).
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
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3. Fig. 2
Spearman's correlation coefficient rho and corresponding P-values for all 42 ROIs. The different colors are used to indicate their correspondence to the ROIs in the ICRS map. * Correlation is significant at the level P < 0.05 (2-tailed). ** Correlation is significant at the level P < 0.01 (2-tailed). + Particularly high correlation. ▼ Low and non-significant correlation. A, Lateral tibiofemoral joint. B, Medial tibiofemoral joint. C, Patellofemoral joint. D, ICRS mapping system for cartilage injuries19; the ROIs selected for this study are colored.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
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4. Fig. 3
T2 mapping and arthroscopy detect low grade damage of the cartilage which is not visible in high-resolution morphological MRI. A, The 3D PD-SPACE MR image shows no significant damage of the cartilage. B, In the corresponding color-coded T2 map can be seen slightly increased T2 relaxation times (in green) in the posterior medial femoral condyle (1) and the medial tibia plateau (2). C, Arthroscopy. * Low grade cartilage damage (ICRS score 1) that is more pronounced in the central and posterior areas.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
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5. Fig. 4
High significance of T2 mapping in moderate cartilage damage. A, Increased T2 relaxation times (in red) in the central (1) and posterior (2) medial femoral condyle and in the medial tibia plateau (3). Cartilage damage (ICRS score 2) was confirmed in arthroscopy. B, Increased T2 relaxation times in the distal medial patella (1) and medial trochlea (2). Despite the low correlation for the distal medial patella T2, mapping correlates well with intraoperative findings (ICRS score 2). * Morphological cartilage lesions.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
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6. Fig. 5
ROC curve (black) and delineation of 95% confidence band of the ROC curve (blue). The bisecting line in the ROC graphs indicates accuracy of random prediction. Marked are the threshold T2 values. AUC = area under the curve, estimated median and 95% confidence interval. A, ROC curve for differentiating clearly between ICRS score 0 and higher ICRS scores. B, ROC curve for differentiating clearly between ICRS score 0/1 and ICRS scores 2, 3, and 4. C, ROC curve for differentiating between ICRS scores 0/1/2 and ICRS scores 3 and 4. No useful ROC curve is available due to the low number of ROIs with ICRS scores 3 and 4 (n = 9). D, Box plots for T2 values per ICRS scores over all patients and ROIs. Box plots show minimum, median, and maximum values. O = outlier.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
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