EGFR signaling in renal fibrosis

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EGFR signaling in renal fibrosis Shougang Zhuang, Na Liu Kidney International Supplements Volume 4, Issue 1, Pages 70-74 (November 2014) DOI: 10.1038/kisup.2014.13 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 Mechanisms of epidermal growth factor receptor (EGFR)-mediated expression of profibrotic factors and activation of renal interstitial fibroblasts. Following chronic kidney injury, histone deacetylases (HDACs) are activated, which induces sustained expression and activation of EGFR, and subsequently triggers epithelial cells arrested in the G2/M phase of the cell cycle. The arrested cells acquire the ability to produce high amounts of transforming growth factor (TGF)-β1 and other profibrotic cytokines, leading to activation of renal interstitial fibroblasts. Kidney International Supplements 2014 4, 70-74DOI: (10.1038/kisup.2014.13) Copyright © 2014 International Society of Nephrology Terms and Conditions