A New Link in the Chain from Amino Acids to mTORC1 Activation Chris G. Proud  Molecular Cell  Volume 44, Issue 1, Pages 7-8 (October 2011) DOI: 10.1016/j.molcel.2011.09.004 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Proposed Complexes Involved in the Control of mTORC1 by Amino Acids (A) The Ragulator complex on the lysosomal surface interacts with Rag GTPases and, in response to amino acids, recruits mTORC1, which can interact with its activator, Rheb.GTP (see Sancak et al., 2010). (B) Duran et al. (2011) now report a distinct complex between p62 and the Rag GTPases that also recruits mTORC1 to the lysosomal surface and promotes formation of active RagB.GTP in response to amino acids. (mLst8, another component of mTOR complexes, is shown for completeness.) Molecular Cell 2011 44, 7-8DOI: (10.1016/j.molcel.2011.09.004) Copyright © 2011 Elsevier Inc. Terms and Conditions