Blood Lead Levels and Decreased Kidney Function in a Population-Based Cohort Florencia Harari, Gerd Sallsten, Anders Christensson, Marinka Petkovic, Bo.

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Blood Lead Levels and Decreased Kidney Function in a Population-Based Cohort Florencia Harari, Gerd Sallsten, Anders Christensson, Marinka Petkovic, Bo Hedblad, Niklas Forsgard, Olle Melander, Peter M. Nilsson, Yan Borné, Gunnar Engström, Lars Barregard American Journal of Kidney Diseases Volume 72, Issue 3, Pages 381-389 (September 2018) DOI: 10.1053/j.ajkd.2018.02.358 Copyright © 2018 The Authors Terms and Conditions

Figure 1 Overview of the Malmö Diet and Cancer Study (Cardiovascular Cohort) at baseline and follow-up. Abbreviations: CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; Pb, lead; Scr, serum creatinine; Scys, serum cystatin C. American Journal of Kidney Diseases 2018 72, 381-389DOI: (10.1053/j.ajkd.2018.02.358) Copyright © 2018 The Authors Terms and Conditions

Figure 2 Incidence of chronic kidney disease (CKD) in relation to blood lead quartiles, adjusted for age, sex, smoking, alcohol intake, hypertension, diabetes mellitus, waist circumference, education level, and estimated glomerular filtration rate (CKD-EPI [CKD Epidemiology Collaboration] creatinine equation) at baseline: (A) quartile 4 (Q4) versus Q1 to Q3 combined, (B) Q2, Q3, and Q4 versus Q1. Number at risk (events) are presented at the bottom of the figure. American Journal of Kidney Diseases 2018 72, 381-389DOI: (10.1053/j.ajkd.2018.02.358) Copyright © 2018 The Authors Terms and Conditions

Figure 3 Forest plot of overall and stratified hazard ratios and 95% confidence intervals (CIs) for incident chronic kidney disease (CKD) in relation to quartiles of blood lead at baseline (comparison of quartile 1 [Q1] to Q3 vs Q4), adjusted for age, sex, smoking, alcohol intake, hypertension, diabetes mellitus, waist circumference, education level, and estimated glomerular filtration rate (CKD-EPI [CKD Epidemiology Collaboration] equation) at baseline. American Journal of Kidney Diseases 2018 72, 381-389DOI: (10.1053/j.ajkd.2018.02.358) Copyright © 2018 The Authors Terms and Conditions