Sean M. Bagshaw, MD, MS, P. Diane Galbraith, BN, MS, L

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Presentation transcript:

Prophylactic Amiodarone for Prevention of Atrial Fibrillation After Cardiac Surgery: A Meta-Analysis Sean M. Bagshaw, MD, MS, P. Diane Galbraith, BN, MS, L. Brent Mitchell, MD, Reg Sauve, MD, Derek V. Exner, MD, MPH, William A. Ghali, MD, MPH The Annals of Thoracic Surgery Volume 82, Issue 5, Pages 1927-1937 (November 2006) DOI: 10.1016/j.athoracsur.2006.06.032 Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Flow diagram of study selection process. (AF = atrial fibrillation; RCTs = randomized controlled trials.) The Annals of Thoracic Surgery 2006 82, 1927-1937DOI: (10.1016/j.athoracsur.2006.06.032) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Forest plot of fixed-effects model of odds ratios for prevention of post–cardiac surgery atrial fibrillation from 19 randomized controlled trials. (CI = confidence interval.) The Annals of Thoracic Surgery 2006 82, 1927-1937DOI: (10.1016/j.athoracsur.2006.06.032) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Cumulative meta-analysis of 19 randomized controlled trials of amiodarone for prevention of post–cardiac surgery atrial fibrillation. The Annals of Thoracic Surgery 2006 82, 1927-1937DOI: (10.1016/j.athoracsur.2006.06.032) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Meta-analysis of secondary outcomes. (A) Forest plot of fixed-effects model for difference in heart rate at onset of atrial fibrillation across 11 studies. (B) Forest plot of random-effects model for difference in hospital length of stay across 11 studies. (C) Forest plot of fixed-effects model for incidence of ventricular tachyarrhythmias across 14 studies. (CI = confidence interval.) (D) Forest plot of fixed-effects model for incidence of transient ischemic attack or stroke across 11 studies. (CI = confidence interval.) The Annals of Thoracic Surgery 2006 82, 1927-1937DOI: (10.1016/j.athoracsur.2006.06.032) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Meta-analysis of secondary outcomes. (A) Forest plot of fixed-effects model for difference in heart rate at onset of atrial fibrillation across 11 studies. (B) Forest plot of random-effects model for difference in hospital length of stay across 11 studies. (C) Forest plot of fixed-effects model for incidence of ventricular tachyarrhythmias across 14 studies. (CI = confidence interval.) (D) Forest plot of fixed-effects model for incidence of transient ischemic attack or stroke across 11 studies. (CI = confidence interval.) The Annals of Thoracic Surgery 2006 82, 1927-1937DOI: (10.1016/j.athoracsur.2006.06.032) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions