Impaired learning and relearning of virtual cued goal localization in Shank2-deficient mice. Impaired learning and relearning of virtual cued goal localization.

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Impaired learning and relearning of virtual cued goal localization in Shank2-deficient mice. Impaired learning and relearning of virtual cued goal localization in Shank2-deficient mice. A, B, The time course of changes in distance traveled (A) and the target period (B) of wild-type (WT, black) and Shank2-deficient mice (KO, red) during training in the nondelayed (ND) and delayed tasks with 1.0- or 1.5-s delay (D1.0 and D1.5). C, D, Average distance traveled (C) and target periods (D) of wild-type (WT) and Shank2-deficient mice (KO) in the early and late phases of ND and D1.5. *p < 0.05; ns, not significant; n = 6–7 mice. E, Histograms showing mouse dwell time and running speed at each position on the track in early and late sessions of the ND (left) and delayed tasks (right) for wild-type (top) and Shank2-deficient mice (bottom). Target periods are indicated in the upper right corner of the time histograms. F, Dwell time histograms of wild-type and Shank2-deficient mice in pre, shift 2 (S2) and shift 4 (S4) sessions of the target shift experiments. The positions of target 1 and target 3 are indicated in red and green, respectively. G, Changes in the target periods in target 1 (red) and target 3 (green) in the target shift experiments for wild-type (left) and Shank2-deficient mice (right). Pr, pre; S, shift. H, Target periods of wild-type and Shank2-deficient mice for target 3 in shift 4 sessions. **p < 0.01, n = 6–7 mice. I, Relearning indices of wild-type and Shank2-deficient mice, which were calculated as net changes in the target periods for target 3 between pre and shift 4 over those for target 1. *p < 0.05, n = 6-7 mice. Masaaki Sato et al. eNeuro 2017;4:ENEURO.0369-16.2017 ©2017 by Society for Neuroscience