Albert M. Levin, PhD, Rasika A

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A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations Albert M. Levin, PhD, Rasika A. Mathias, ScD, Lili Huang, MPH, Lindsey A. Roth, MA, Denise Daley, PhD, Rachel A. Myers, PhD, Blanca E. Himes, PhD, Isabelle Romieu, MD, ScD, Mao Yang, MS, Celeste Eng, BS, Julie E. Park, MMath, Karla Zoratti, Christopher R. Gignoux, MS, Dara G. Torgerson, PhD, Joshua M. Galanter, MD, Scott Huntsman, MS, Elizabeth A. Nguyen, BS, Allan B. Becker, MD, Moira Chan-Yeung, MD, Anita L. Kozyrskyj, PhD, Pui-Yan Kwok, MD, PhD, Frank D. Gilliland, MD, PhD, W. James Gauderman, PhD, Eugene R. Bleecker, MD, Benjamin A. Raby, MD, MPH, Deborah A. Meyers, PhD, Stephanie J. London, MD, DrPH, Fernando D. Martinez, MD, Scott T. Weiss, MD, MS, Esteban G. Burchard, MD, MPH, Dan L. Nicolae, PhD, Carole Ober, PhD, Kathleen C. Barnes, PhD, L. Keoki Williams, MD, MPH Journal of Allergy and Clinical Immunology Volume 131, Issue 4, Pages 1176-1184 (April 2013) DOI: 10.1016/j.jaci.2012.10.002 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Manhattan plot of the genome-wide association results for serum total IgE levels from the meta-analysis. The significance level used to promote SNPs for replication (P < 5.0 × 10−6) is denoted by the dashed line. The solid line shows the genome-wide significance level at a P value of less than 5.0 × 10−8. Journal of Allergy and Clinical Immunology 2013 131, 1176-1184DOI: (10.1016/j.jaci.2012.10.002) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Locus zoom plots of rs9469220 (triangles) located between HLA-DQB1 and HLA-DQA2 on chromosome 6 and its association with serum total IgE levels. The plots show the association P values (derived from the genome-wide meta-analysis) and the LD (with rs9469220) in color for the surrounding SNPs in European American subjects (A), African American subjects (B), and Latino subjects (C). The polymorphism near HLA-DQA2, rs2858331, as identified by Granada et al47 is also shown (squares). Journal of Allergy and Clinical Immunology 2013 131, 1176-1184DOI: (10.1016/j.jaci.2012.10.002) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions