Enzyme-modified wheat gliadin activates T cells in celiac disease

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Enzyme-modified wheat gliadin activates T cells in celiac disease Dan Gordon  Gastroenterology  Volume 115, Issue 4, (October 1998) DOI: 10.1016/S0016-5085(98)70247-1 Copyright © 1998 Terms and Conditions

Fig. 1 Possible mechanism by which tissue transglutaminase enables gliadin to activate susceptible mucosal T cells. Transglutaminase forms a physical linkage to glutamine residues in gliadin, then catalyzes a formation of a peptide bond between glutamic acid residue formed by removing ammonia from glutamine with lysine residues in the T-cell DQ2 binding pocket. Gastroenterology 1998 115, DOI: (10.1016/S0016-5085(98)70247-1) Copyright © 1998 Terms and Conditions

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