Incomplete digestion of codfish represents a risk factor for anaphylaxis in patients with allergy Eva Untersmayr, MD, Helle Vestergaard, Hans-Jørgen.

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Presentation transcript:

Incomplete digestion of codfish represents a risk factor for anaphylaxis in patients with allergy Eva Untersmayr, MD, Helle Vestergaard, Hans-Jørgen Malling, MD, Louise Bjerremann Jensen, MSc, Michael H. Platzer, PhD, George Boltz-Nitulescu, PhD, Otto Scheiner, PhD, Per Stahl Skov, MD, PhD, Erika Jensen-Jarolim, MD, Lars K. Poulsen, PhD Journal of Allergy and Clinical Immunology Volume 119, Issue 3, Pages 711-717 (March 2007) DOI: 10.1016/j.jaci.2006.10.039 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Time dependency of codfish absorption in healthy individuals. Serum samples drawn 10, 30, 60, 120, and 180 minutes after a codfish meal were analyzed for histamine release capacity with passively sensitized basophils. The quantity of circulating codfish antigen is relatively represented by the amount of released histamine. Data from 3 subjects are presented as means ± SDs. Journal of Allergy and Clinical Immunology 2007 119, 711-717DOI: (10.1016/j.jaci.2006.10.039) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Codfish proteins are exclusively digested in SGF at low pH. Codfish SPT substance (A,1) and codfish protein extract for DBPCFC (B,1) were subjected to gastric digestion assays at acidic (pH 2.0; 2-4) and hypoacidic conditions (pH 3.0; 5-7) for 1 minute (2, 5), 15 minutes (3, 6), and 2 hours (4, 7). Journal of Allergy and Clinical Immunology 2007 119, 711-717DOI: (10.1016/j.jaci.2006.10.039) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Gastric digestion reduces capacity of codfish allergens to trigger skin reactions. SPTs were performed with undigested substances (1-4) or samples digested at pH 2.0 (5-9) and pH 3.0 (10-14) for 1 minute (5-7 and 10-12), 15 minutes (8, 13), and 2 hours (9, 14; dark grey), diluted 1:10 (2, 6, 11), 1:100 (3, 7, 12), and 1:1000 (4; light grey). Boxes represent the size of wheal reactions of 5 patients with codfish allergy (∗P = .009; ∗∗P = .016). Journal of Allergy and Clinical Immunology 2007 119, 711-717DOI: (10.1016/j.jaci.2006.10.039) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions