Asif Rashid, Jean Pierre J. Issa  Gastroenterology 

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CpG island methylation in gastroenterologic neoplasia: A maturing field  Asif Rashid, Jean Pierre J. Issa  Gastroenterology  Volume 127, Issue 5, Pages 1578-1588 (November 2004) DOI: 10.1053/j.gastro.2004.09.007 Copyright © 2004 American Gastroenterological Association Terms and Conditions

Figure 1 Model of the DNA methylation-associated gene silencing loop in cancer. The cascade of events may start with DNA methylation triggering histone modifications or with histone H3 lysine-9 (K9) methylation triggering silencing, which then promotes DNA methylation. Gastroenterology 2004 127, 1578-1588DOI: (10.1053/j.gastro.2004.09.007) Copyright © 2004 American Gastroenterological Association Terms and Conditions

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