Genomewide Scan for Prostate Cancer–Aggressiveness Loci

Slides:

Advertisements

Similar presentations

Connexin Mutations in Skin Disease and Hearing Loss David P. Kelsell, Wei-Li Di, Mark J. Houseman The American Journal of Human Genetics Volume 68, Issue.

Advertisements

Functional Analysis of the Neurofibromatosis Type 2 Protein by Means of Disease- Causing Point Mutations Renee P. Stokowski, David R. Cox The American.

Gene Preference in Maple Syrup Urine Disease Mary M. Nellis, Dean J. Danner The American Journal of Human Genetics Volume 68, Issue 1, Pages (January.

Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part I: Methods and Power Analysis Douglas F. Levinson, Matthew D. Levinson, Ricardo Segurado,

Genomewide Comparison of DNA Sequences between Humans and Chimpanzees Ingo Ebersberger, Dirk Metzler, Carsten Schwarz, Svante Pääbo The American Journal.

The Duty to Recontact: Attitudes of Genetics Service Providers Jennifer L. Fitzpatrick, Cecil Hahn, Teresa Costa, Marlene J. Huggins The American Journal.

PRIMUS: Rapid Reconstruction of Pedigrees from Genome-wide Estimates of Identity by Descent Jeffrey Staples, Dandi Qiao, Michael H. Cho, Edwin K. Silverman,

Peopling of Sahul: mtDNA Variation in Aboriginal Australian and Papua New Guinean Populations Alan J. Redd, Mark Stoneking The American Journal of Human.

Quantitative-Trait-Locus Analysis of Body-Mass Index and of Stature, by Combined Analysis of Genome Scans of Five Finnish Study Groups Markus Perola,

Genome Scan for Predisposing Loci for Distal Interphalangeal Joint Osteoarthritis: Evidence for a Locus on 2q Jenni Leppävuori, Urho Kujala, Jaakko Kinnunen,

Human Pedigree-Based Quantitative-Trait–Locus Mapping: Localization of Two Genes Influencing HDL-Cholesterol Metabolism Laura Almasy, James E. Hixson,

Genomewide Linkage Analysis Identifies Polymorphism in the Human Interferon-γ Receptor Affecting Helicobacter pylori Infection Thorsten Thye, Gerd D.

Transmission/Disequilibrium Tests for Extended Marker Haplotypes

M. A. Escamilla, M. C. DeMille, E. Benavides, E. Roche, L. Almasy, S

Daniel J. Schaid, Charles M. Rowland, David E. Tines, Robert M

Rapid Simulation of P Values for Product Methods and Multiple-Testing Adjustment in Association Studies S.R. Seaman, B. Müller-Myhsok The American Journal.

Human Diallelic Insertion/Deletion Polymorphisms

Comparison of Microsatellites Versus Single-Nucleotide Polymorphisms in a Genome Linkage Screen for Prostate Cancer–Susceptibility Loci Daniel J. Schaid,

Model-Free Linkage Analysis with Covariates Confirms Linkage of Prostate Cancer to Chromosomes 1 and 4 Katrina A.B. Goddard, John S. Witte, Brian K.

Soraya Beiraghi, Swapan K. Nath, Matthew Gaines, Desh D

Frances Busfield, David L. Duffy, Janine B. Kesting, Shelley M

Genomewide Linkage Scan Identifies a Novel Susceptibility Locus for Restless Legs Syndrome on Chromosome 9p Shenghan Chen, William G. Ondo, Shaoqi Rao,

A Major Susceptibility Locus Influencing Plasma Triglyceride Concentrations Is Located on Chromosome 15q in Mexican Americans Ravindranath Duggirala,

Genomewide Linkage Scan for Myopia Susceptibility Loci among Ashkenazi Jewish Families Shows Evidence of Linkage on Chromosome 22q12 Dwight Stambolian,

Genetic Linkage Analysis of a Dichotomous Trait Incorporating a Tightly Linked Quantitative Trait in Affected Sib Pairs Jian Huang, Yanming Jiang The.

A Whole-Genome Scan in 164 Dutch Sib Pairs with Attention-Deficit/Hyperactivity Disorder: Suggestive Evidence for Linkage on Chromosomes 7p and 15q S.C.

Meta-analysis of Genetic-Linkage Analysis of Quantitative-Trait Loci

Linkage Thresholds for Two-stage Genome Scans

A Combined Linkage-Physical Map of the Human Genome

Genetics, Individuality, and Medicine in the 21st Century*

A Unified Sampling Approach for Multipoint Analysis of Qualitative and Quantitative Traits in Sib Pairs Kung-Yee Liang, Chiung-Yu Huang, Terri H. Beaty

The American Journal of Human Genetics

XMCPDT Does Have Correct Type I Error Rates

Reduction of Sample Heterogeneity through Use of Population Substructure: An Example from a Population of African American Families with Sarcoidosis

Susan M. Farrington, Juili Lin-Goerke, Jessica Ling, Yute Wang, John D

Danielle Posthuma, Michelle Luciano, Eco J. C. de Geus, Margie J

Genomewide Scan for Prostate Cancer–Aggressiveness Loci

Lue Ping Zhao, Ross Prentice, Fumin Shen, Li Hsu

Chuanhui Dong, Wei-Dong Li, Frank Geller, Lei Lei, Ding Li, Olga Y

Assessment of the Effect of Age at Onset on Linkage to Bipolar Disorder: Evidence on Chromosomes 18p and 21q Ping-I Lin, Melvin G. McInnis, James B.

A Genomewide Search Finds Major Susceptibility Loci for Nicotine Dependence on Chromosome 10 in African Americans Ming D. Li, Thomas J. Payne, Jennie.

A Locus for Hereditary Sensory Neuropathy with Cough and Gastroesophageal Reflux on Chromosome 3p22-p24 C. Kok, M.L. Kennerson, P.J. Spring, A.J. Ing,

Stephen C. Pratt, Mark J. Daly, Leonid Kruglyak

Model-Free Linkage Analysis with Covariates Confirms Linkage of Prostate Cancer to Chromosomes 1 and 4 Katrina A.B. Goddard, John S. Witte, Brian K.

Erratum The American Journal of Human Genetics

A Genomewide Linkage Scan for Quantitative-Trait Loci for Obesity Phenotypes Hong-Wen Deng, Hongyi Deng, Yong-Jun Liu, Yao-Zhong Liu, Fu-Hua Xu, Hui Shen,

Genomewide Linkage Analyses of Bipolar Disorder: A New Sample of 250 Pedigrees from the National Institute of Mental Health Genetics Initiative Danielle.

Linkage Analysis Identifies a Novel Locus for Restless Legs Syndrome on Chromosome 2q in a South Tyrolean Population Isolate Irene Pichler, Fabio Marroni,

William F. Forrest, Eleanor Feingold

Michael P. Epstein, Xihong Lin, Michael Boehnke

Benjamin A. Rybicki, Robert C. Elston

A Severely Affected Male Born into a Rett Syndrome Kindred Supports X-Linked Inheritance and Allows Extension of the Exclusion Map Carolyn Schanen, Uta.

James A. Lautenberger, J. Claiborne Stephens, Stephen J

Long Homozygous Chromosomal Segments in Reference Families from the Centre d'Étude du Polymorphisme Humain Karl W. Broman, James L. Weber The American.

Genomewide Linkage Analysis of Quantitative Spirometric Phenotypes in Severe Early- Onset Chronic Obstructive Pulmonary Disease Edwin K. Silverman, Lyle.

A Fast, Powerful Method for Detecting Identity by Descent

Nonpaternity in Linkage Studies of Extremely Discordant Sib Pairs

David B. Allison, Bonnie Thiel, Pamela St. Jean, Robert C

Genomewide Linkage Study in 1,176 Affected Sister Pair Families Identifies a Significant Susceptibility Locus for Endometriosis on Chromosome 10q26 Susan.

Position of the American Dietetic Association: Vegetarian Diets

Genomewide Search and Genetic Localization of a Second Gene Associated with Autosomal Dominant Branchio-Oto-Renal Syndrome: Clinical and Genetic Implications

American Journal of Kidney Diseases

Linkage Analyses at the Chromosome 1 Loci 1q24-25 (HPC1), 1q42

Amalia Martinez-Mir, Jianjun Liu, Derek Gordon, Madeline S

Identification of Genetic Markers Associated with Gilles de la Tourette Syndrome in an Afrikaner Population Ingrid Simonic, George S. Gericke, Jurg Ott,

Tao Wang, Robert C. Elston The American Journal of Human Genetics

A Quantitative-Trait Locus on Chromosome 6p Influences Different Aspects of Developmental Dyslexia Simon E. Fisher, Angela J. Marlow, Janine Lamb, Elena.

Genetic Linkage Analysis of a Dichotomous Trait Incorporating a Tightly Linked Quantitative Trait in Affected Sib Pairs Jian Huang, Yanming Jiang The.

Sanjay Shete, Xiaojun Zhou, Christopher I. Amos

B. Yuan, R. Neuman, S. H. Duan, J. L. Weber, P. Y. Kwok, N. L

Presentation transcript:

Genomewide Scan for Prostate Cancer–Aggressiveness Loci John S. Witte, Katrina A.B. Goddard, David V. Conti, Robert C. Elston, Jennifer Lin, Brian K. Suarez, Karl W. Broman, James K. Burmester, James L. Weber, William J. Catalona The American Journal of Human Genetics Volume 67, Issue 1, Pages 92-99 (July 2000) DOI: 10.1086/302960 Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 1 Results from a genomewide scan of PCa-aggressiveness genes; Gleason score was used as a quantitative trait. Unbroken lines denote results from the new HE analysis; broken lines denote results from the original HE analysis. Tick marks across horizontal axes indicate marker locations (in cM) (as specified on the Center for Human Genetics, Marshfield Medical Research Foundation Web site). P values are from a t test of the HE regression coefficient, with 324 df (number of affected sib pairs [326] minus the number of parameters [2]). Dotted horizontal lines indicate where P=.001 (−log[P] = 3); thus, for peaks above these lines, P<.001. The American Journal of Human Genetics 2000 67, 92-99DOI: (10.1086/302960) Copyright © 2000 The American Society of Human Genetics Terms and Conditions