1. Composite Statistics for QTL Mapping with Moderately Discordant Sibling Pairs 
William F. Forrest, Eleanor Feingold 
The American Journal of Human Genetics 
Volume 66, Issue 5, Pages (May 2000)
DOI: /302897
Copyright © 2000 The American Society of Human Genetics Terms and Conditions

2. Figure 1
Power curves and scatter plots of the component test statistics over 10,000 replications for the simulation experiment. 1.a–1.1.c refer to the linkage analysis with a population sample of sib pairs. 1.a, power curves when θ=0 for the Haseman-Elston test ( ), the mean IBD test (— — — —) and the composite test (————) over the five sample sizes considered. 1.b and 1.c, paired values for the Haseman-Elston test statistic and the mean IBD test for the cases θ=½ and θ=0, respectively, for a population sample of 200 sib pairs. 2.a–2.c show the corresponding plots for MDSP samples. In 2.b and 2.c, 200 MDSPs are analyzed in each of the 10,000 replications for θ=½ and θ=0, respectively. 3.a and 3.c show the corresponding plots for EDSP samples. In 3.b and 3.c, 100 EDSPs are analyzed in each of the 10,000 replications for θ=½ and θ=0, respectively.
The American Journal of Human Genetics  , DOI: ( /302897)
Copyright © 2000 The American Society of Human Genetics Terms and Conditions

3. Figure 2
LOD scores for the three methods, computed at 1-cM spacing along chromosome 8 for 204 moderately discordant sibling pairs taken from the first 717 (i.e., three replications) GAW10 problem 2A nuclear families. Ascertainment is such that one sib falls into the top 35% of the trait distribution and the other into the bottom 35%.
The American Journal of Human Genetics  , DOI: ( /302897)
Copyright © 2000 The American Society of Human Genetics Terms and Conditions

4. Figure 3
a, bivariate scatter plot of 5,000 trait pairs for simulated sib pairs ascertained at random from the population. The points are well described by a bivariate normal distribution. b, bivariate scatter plot of 5,000 trait pairs for simulated sib pairs ascertained subject to the restriction that one trait fall into the lower 35% of the trait distribution and the other into the upper 35% of the distribution. The points are restricted to two diametrically opposed regions because of the ascertainment scheme and, thus, are not well described by a bivariate normal distribution.
The American Journal of Human Genetics  , DOI: ( /302897)
Copyright © 2000 The American Society of Human Genetics Terms and Conditions