Tissue-specific glucocorticoid resistance-hypersensitivity syndromes: Multifactorial states of clinical importance  Tomoshige Kino, MD, PhD, George P. Chrousos, MD  Journal of Allergy and Clinical Immunology  Volume 109, Issue 4, Pages 609-613 (April 2002) DOI: 10.1067/mai.2002.123708 Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 1 A , Circulation of the GR between the cytoplasm and the nucleus and its transactivating or transrepressive activities. GRE , Glucocorticoid-responsive elements; TF , transcription factor; TFRE , transcription factor-responsive element; HSP , heat shock protein. B, Genomic and complementary DNA and protein structures of the human GR. The human GR gene consists of 10 exons. Exon 1 is an untranslated region, exon 2 codes for the immunogenic domain (A and B ), exon 3 and 4 code for the DNA-binding domain (C) , and exons 5 to 9 code for the hinge region (D) and the ligand-binding domain (E) . The gene encoding GR contains 2 terminal exons 9 (exon 9α and 9β) alternatively spliced to produce the classic GRα and the non–ligand-binding GRβ. C-terminal gray-colored domains in GRα and GRβ show their specific portions. C, Functional domains of the GRα. Functional domains and subdomains are indicated. HR, Hinge region; NL1 and NL2, nuclear translocation signals 1 and 2. Journal of Allergy and Clinical Immunology 2002 109, 609-613DOI: (10.1067/mai.2002.123708) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 1 A , Circulation of the GR between the cytoplasm and the nucleus and its transactivating or transrepressive activities. GRE , Glucocorticoid-responsive elements; TF , transcription factor; TFRE , transcription factor-responsive element; HSP , heat shock protein. B, Genomic and complementary DNA and protein structures of the human GR. The human GR gene consists of 10 exons. Exon 1 is an untranslated region, exon 2 codes for the immunogenic domain (A and B ), exon 3 and 4 code for the DNA-binding domain (C) , and exons 5 to 9 code for the hinge region (D) and the ligand-binding domain (E) . The gene encoding GR contains 2 terminal exons 9 (exon 9α and 9β) alternatively spliced to produce the classic GRα and the non–ligand-binding GRβ. C-terminal gray-colored domains in GRα and GRβ show their specific portions. C, Functional domains of the GRα. Functional domains and subdomains are indicated. HR, Hinge region; NL1 and NL2, nuclear translocation signals 1 and 2. Journal of Allergy and Clinical Immunology 2002 109, 609-613DOI: (10.1067/mai.2002.123708) Copyright © 2002 Mosby, Inc. Terms and Conditions