by Giridharan Ramsingh, Meagan A. Jacoby, Jin Shao, Rigoberto E

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Acquired copy number alterations of miRNA genes in acute myeloid leukemia are uncommon by Giridharan Ramsingh, Meagan A. Jacoby, Jin Shao, Rigoberto E. De Jesus Pizzaro, Dong Shen, Maria Trissal, Angela H. Getz, Timothy J. Ley, Matthew J. Walter, and Daniel C. Link Blood Volume 122(15):e44-e51 October 10, 2013 ©2013 by American Society of Hematology

Hemizygous loss of MIR-223 in a patient with AML Hemizygous loss of MIR-223 in a patient with AML. (A) Log2 ratio dot plots of paired tumor and normal DNA from patient UPN 864484 analyzed by using the custom CGH array. Hemizygous loss of MIR-223 in a patient with AML. (A) Log2 ratio dot plots of paired tumor and normal DNA from patient UPN 864484 analyzed by using the custom CGH array. A discrete deletion of approximately 429 kb on chromosome X is depicted. Genomic coordinates are based on NCIBI36/HG18 assembly. (B) Quantitative PCR for MIR223 and MIR181b (control gene) was performed by using genomic DNA from the indicated source. Shown is the ratio of MIR223 to MIR181b signal. Data represent the mean ± standard error of the mean of triplicate measurements. (C) miR-223 expression relative to RNU48 is shown for CD34+ cells isolated from healthy donors (CD34) and leukemic bone marrow from patient UPN 864484 or 28 other patients with AML. The 90% confidence interval is shown for CD34+ cells. Giridharan Ramsingh et al. Blood 2013;122:e44-e51 ©2013 by American Society of Hematology