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Stem cell concepts renew cancer research by John E. Dick Blood Volume 112(13):4793-4807 December 15, 2008 ©2008 by American Society of Hematology.

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Presentation on theme: "Stem cell concepts renew cancer research by John E. Dick Blood Volume 112(13):4793-4807 December 15, 2008 ©2008 by American Society of Hematology."— Presentation transcript:

1 Stem cell concepts renew cancer research by John E. Dick Blood Volume 112(13):4793-4807 December 15, 2008 ©2008 by American Society of Hematology

2 John E. Dick. John E. Dick Blood 2008;112:4793-4807 ©2008 by American Society of Hematology

3 Labeling pattern of leukemic cells in marrow of patient 1. John E. Dick Blood 2008;112:4793-4807 ©2008 by American Society of Hematology

4 Models of tumor heterogeneity. John E. Dick Blood 2008;112:4793-4807 ©2008 by American Society of Hematology

5 Hierarchy of leukemia stem cells in AML. Like the normal hematopoietic system, AML is organized as a hierarchy of distinct cell classes that is sustained by a subset of leukemia stem cells (or SCID-leukemia initiating cells [SL-ICs], as assayed in immunodef... John E. Dick Blood 2008;112:4793-4807 ©2008 by American Society of Hematology

6 Models of tumor initiation and progression. John E. Dick Blood 2008;112:4793-4807 ©2008 by American Society of Hematology


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