A New Map for Navigating the Yeast Epigenome

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A New Map for Navigating the Yeast Epigenome Dirk Schübeler, Bryan M. Turner Cell Volume 122, Issue 4, Pages 489-492 (August 2005) DOI: 10.1016/j.cell.2005.08.007 Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 1 Distribution of Histone Modifications across a Typical Yeast Gene In their ChIP-chip assay, Pokholok et al. (2005) immunoprecipitated formaldehyde-crosslinked yeast chromatin with antibodies to acetylated histones H3 and H4, and to H3 histone mono-, di-, or trimethylated at lysine 36 (H3K36), lysine 79 (H3K79), and lysine 4 (H3K4). The authors amplified immunoprecipitated and input DNA by ligation-mediated PCR, labeled them with different fluorescent dyes, and mixed and hybridized them to a single DNA microarray. The ratio of both fluorescent dyes on each spot provides a measure of the relative enrichment of the histone modification under investigation. Collectively, this provides information with which to construct a genome-wide map of the consensus distribution of histone modifications in yeast. Each of the distributions shown represents a composite profile derived from several hundred genes. Cell 2005 122, 489-492DOI: (10.1016/j.cell.2005.08.007) Copyright © 2005 Elsevier Inc. Terms and Conditions