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Decoding Chromatin Goes High Tech

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Presentation on theme: "Decoding Chromatin Goes High Tech"— Presentation transcript:

1 Decoding Chromatin Goes High Tech
Dan Levy, Or Gozani  Cell  Volume 142, Issue 6, Pages (September 2010) DOI: /j.cell Copyright © 2010 Elsevier Inc. Terms and Conditions

2 Figure 1 Readers Determine the Effects of Lysine Methylation
The schematic depicts three different models for how methyllysine readers can sense and transduce histone methylation marks into biological outcomes. (A) A specific reader recognizes one mark and links it to one specific outcome. In this way, distinct readers link different marks to alternate functional outcomes. (B) Five distinct readers all specifically recognize the same mark, for example trimethylated histone H3 lysine 4 (H3K4me3), resulting in five alternate biological outputs being linked to the one mark. (C) One reader binds to multiple different marks (such as H3K9me3, H3K27me3, and H4K20me3), linking the three different marks to a single biological output. Cell  , DOI: ( /j.cell ) Copyright © 2010 Elsevier Inc. Terms and Conditions

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