Sang-Hee Yoon, M. D. , Ji Young Lee, M. D. , Soo-Nyung Kim, M. D

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Presentation transcript:

Does salpingectomy have a deleterious impact on ovarian response in in vitro fertilization cycles? Sang-Hee Yoon, M.D., Ji Young Lee, M.D., Soo-Nyung Kim, M.D., Hye Won Chung, M.D., So Yun Park, M.D., Chulmin Lee, M.D. Fertility and Sterility Volume 106, Issue 5, Pages 1083-1092.e5 (October 2016) DOI: 10.1016/j.fertnstert.2016.05.030 Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Flow diagram of the literature search procedure (PRISMA 2009 flow diagram). Fertility and Sterility 2016 106, 1083-1092.e5DOI: (10.1016/j.fertnstert.2016.05.030) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Forest plot comparing (A) the peak E2 level, (B) total gonadotropin dose used, (C) number of oocytes retrieved, and (D) number of pregnancies post- and presalpingectomy. Fertility and Sterility 2016 106, 1083-1092.e5DOI: (10.1016/j.fertnstert.2016.05.030) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Funnel plot of standard error by standard difference in means for (A) peak E2 level, (B) total doses of gonadotropin used, and (C) number of oocytes retrieved post- and presalpingectomy. Funnel plot of standard error by log OR for (D) number of pregnancies post- and presalpingectomy. (E) The trim-and-fill method estimated the presence of three potentially unreported studies. After these three potentially unpublished studies were filled, the resulting adjusted OR was 1.06 (95% CI, 0.79, 1.45) in the fixed-effects model. Fertility and Sterility 2016 106, 1083-1092.e5DOI: (10.1016/j.fertnstert.2016.05.030) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 The MD in (A) peak E2 level, (B) total doses of gonadotropin used, and (C) number of oocytes retrieved after salpingectomy: relationship between follow-up period after salpingectomy and size of effect. Fertility and Sterility 2016 106, 1083-1092.e5DOI: (10.1016/j.fertnstert.2016.05.030) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 The MD in (A) peak E2 level, (B) total doses of gonadotropin used, and (C) number of oocytes retrieved after salpingectomy: pooled result for studies with analysis of changes in peak E2 level stratified by before salpingectomy. (D) The OR for pregnancy incidence comparing postsalpingectomy with presalpingectomy in a meta-analysis based on the fixed-effects model. Fertility and Sterility 2016 106, 1083-1092.e5DOI: (10.1016/j.fertnstert.2016.05.030) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 3 In subgroup meta-analysis by the study design, forest plot comparing (A) the peak E2 level, (B) total gonadotropin dose used, and (C) number of oocytes retrieved post- and presalpingectomy. Fertility and Sterility 2016 106, 1083-1092.e5DOI: (10.1016/j.fertnstert.2016.05.030) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 4 In subgroup meta-analysis by the indication of surgery, forest plot comparing (A) the peak E2 level, (B) total gonadotropin dose used, (C) number of oocytes retrieved, and (D) number of pregnancies post- and presalpingectomy. Fertility and Sterility 2016 106, 1083-1092.e5DOI: (10.1016/j.fertnstert.2016.05.030) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions