Pharmacokinetics and follicular dynamics of corifollitropin alfa versus recombinant FSH during ovarian stimulation for IVF Bart C.J.M. Fauser, Michael.

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Presentation transcript:

Pharmacokinetics and follicular dynamics of corifollitropin alfa versus recombinant FSH during ovarian stimulation for IVF Bart C.J.M. Fauser, Michael M. Alper, William Ledger, William B Schoolcraft, Anthe Zandvliet, Bernadette M.J.L. Mannaerts Reproductive BioMedicine Online Volume 21, Issue 5, Pages 593-601 (November 2010) DOI: 10.1016/j.rbmo.2010.06.032 Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Time profiles of (A) serum recombinant FSH (rFSH) immunoreactivity, (B) serum oestradiol and (C) inhibin B concentrations for the corifollitropin alfa regimen and the daily rFSH regimen. All-subjects-treated population, restricted to subjects with human chorionic gonadotrophin (HCG) injection, from day of stimulation to 2 weeks after embryo transfer (ET). Horizontal black marks represent median values, boxes represent interquartile ranges and whiskers represent 5–95% percentiles. Reproductive BioMedicine Online 2010 21, 593-601DOI: (10.1016/j.rbmo.2010.06.032) Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Serum FSH immunoreactivity concentrations on (A) stimulation day 8 and (B) the day of human chorionic gonadotrophin (HCG) administration for the corifollitropin alfa regimen and the daily recombinant FSH (rFSH) regimen. Horizontal black marks represent median values, boxes represent interquartile ranges and whiskers represent 5–95% percentiles. Reproductive BioMedicine Online 2010 21, 593-601DOI: (10.1016/j.rbmo.2010.06.032) Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions

Figure 3 Proportion of subjects with at least three follicles with a diameter of ⩾17mm by day the criterion for human chorionic gonadotrophin (HCG) administration was met, for (A) corifollitropin alfa regimen and (B) daily recombinant FSH (rFSH) regimen. All-subjects-treated population. Reproductive BioMedicine Online 2010 21, 593-601DOI: (10.1016/j.rbmo.2010.06.032) Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions

Figure 4 Time profiles of concentrations of (A) serum LH and (B) progesterone for the corifollitropin alfa regimen and the daily recombinant FSH (rFSH) regimen. All-subjects-treated population, restricted to subjects with human chorionic gonadotrophin (HCG) injection, from day of stimulation to 2 weeks after embryo transfer (ET). Horizontal black marks represent median values, boxes represent interquartile ranges and whiskers represent 5–95% percentiles. Reproductive BioMedicine Online 2010 21, 593-601DOI: (10.1016/j.rbmo.2010.06.032) Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions

Figure 5 Mean±SD follicles ⩾11mm during stimulation and on the day of human chorionic gonadotrophin (HCG) administration for the corifollitropin alfa regimen and the daily recombinant follicle-stimulating hormone (rFSH) regimen. All-subjects-treated population. Reproductive BioMedicine Online 2010 21, 593-601DOI: (10.1016/j.rbmo.2010.06.032) Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions

Figure 6 Mean number and size distribution of follicles ⩾11mm for the corifollitropin alfa regimen and the daily recombinant follicle-stimulating hormone (rFSH) regimen. All-subjects-treated population. Reproductive BioMedicine Online 2010 21, 593-601DOI: (10.1016/j.rbmo.2010.06.032) Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions