Total Colony-Forming Units Are a Strong, Independent Predictor of Neutrophil and Platelet Engraftment after Unrelated Umbilical Cord Blood Transplantation:

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Presentation transcript:

Total Colony-Forming Units Are a Strong, Independent Predictor of Neutrophil and Platelet Engraftment after Unrelated Umbilical Cord Blood Transplantation: A Single- Center Analysis of 435 Cord Blood Transplants Kristin M. Page, Lijun Zhang, Adam Mendizabal, Stephen Wease, Shelly Carter, Tracy Gentry, Andrew E. Balber, Joanne Kurtzberg Biology of Blood and Marrow Transplantation Volume 17, Issue 9, Pages 1362-1374 (September 2011) DOI: 10.1016/j.bbmt.2011.01.011 Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Impact of precryo graft characteristics on the probability of neutrophil engraftment. Probability plots are shown for each of the 4 quartiles. Panels A-D depict the impact of precryo TNC (×107/kg recipient weight), MNC (×107/kg recipient weight), CD34+ (×105/kg recipient weight), and CFU (×104/kg recipient weight) doses, respectively, on neutrophil engraftment. Biology of Blood and Marrow Transplantation 2011 17, 1362-1374DOI: (10.1016/j.bbmt.2011.01.011) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Impact of postthaw graft characteristics on the probability of neutrophil engraftment. Probability plots are shown for each of the 4 quartiles. Panels A-D depict the impact of post-thaw TNC (×107/kg recipient weight), MNC (×107/kg recipient weight), CD34+ (×105/kg recipient weight), and CFU (×104/kg recipient weight) doses, respectively, on neutrophil engraftment. Biology of Blood and Marrow Transplantation 2011 17, 1362-1374DOI: (10.1016/j.bbmt.2011.01.011) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Impact of precryo graft characteristics on the probability of platelet engraftment. Probability plots are shown for each of the 4 quartiles. Panels A-D depict the impact of precryo TNC (×107/kg recipient weight), MNC (×107/kg recipient weight), CD34+ (×105/kg recipient weight), and CFU (×104/kg recipient weight) doses, respectively, on platelet engraftment. Biology of Blood and Marrow Transplantation 2011 17, 1362-1374DOI: (10.1016/j.bbmt.2011.01.011) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Impact of post-thaw graft characteristics on the probability of platelet engraftment. Probability plots are shown for each of the 4 quartiles. Panels A-D depict the impact of post-thaw TNC (×107/kg recipient weight), MNC (×107/kg recipient weight), CD34+ (×105/kg recipient weight), and CFU (×104/kg recipient weight) doses, respectively, on platelet engraftment. Biology of Blood and Marrow Transplantation 2011 17, 1362-1374DOI: (10.1016/j.bbmt.2011.01.011) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 5 Availability of CBUs in a large public bank (n = 22,559), which contain high CFU cell doses for various patient weights. For various theoretical patient weights, we have presented the percentage of CBUs available in a large, public cord blood bank (Carolinas Cord Blood Bank at Duke). CBUs all met criteria for banking as specified by the National Cord Blood Inventory. Biology of Blood and Marrow Transplantation 2011 17, 1362-1374DOI: (10.1016/j.bbmt.2011.01.011) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions