Prognostic Factors Affecting Outcome after Allogeneic Transplantation for Hematological Malignancies from Unrelated Donors: Results from a Randomized.

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Presentation transcript:

Prognostic Factors Affecting Outcome after Allogeneic Transplantation for Hematological Malignancies from Unrelated Donors: Results from a Randomized Trial Jürgen Finke, Claudia Schmoor, Wolfgang A. Bethge, Hellmut D. Ottinger, Matthias Stelljes, Axel R. Zander, Liisa Volin, Dominik A. Heim, Rainer Schwerdtfeger, Karin Kolbe, Jiri Mayer, Johan A. Maertens, Werner Linkesch, Ernst Holler, Vladimir Koza, Martin Bornhäuser, Hermann Einsele, Hartmut Bertz, Olga Grishina, Gérard Socié Biology of Blood and Marrow Transplantation Volume 18, Issue 11, Pages 1716-1726 (November 2012) DOI: 10.1016/j.bbmt.2012.06.001 Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Effect of donor age, estimated from multiple regression model (Table 2). (A) Effect on acute graft-versus-host disease (aGVHD) III-IV, hazard ratio (≥40 versus <40 yr) = 2.57; 95% confidence interval (CI), 1.27-5.21; P = .009. (B) Effect on extensive chronic graft-versus-host disease (cGVHD), hazard ratio (≥40 versus <40 yr) = 2.06; 95% CI, 1.12-3.79; P = .021. (C) Effect on overall survival, hazard ratio (≥40 versus <40 yr) = 1.66; 95% CI, 1.10-2.51; P = .016. Biology of Blood and Marrow Transplantation 2012 18, 1716-1726DOI: (10.1016/j.bbmt.2012.06.001) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Effect of treatment and HLA-mismatch. (A) Effect on acute graft-versus-host disease (aGVHD) III-IV. (B) Effect on extensive chronic graft-versus-host disease (cGVHD). (C) Effect on relapse. Biology of Blood and Marrow Transplantation 2012 18, 1716-1726DOI: (10.1016/j.bbmt.2012.06.001) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions