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Allogeneic Stem Cell Transplantation for Patients Age ≥ 70 Years with Myelodysplastic Syndrome: A Retrospective Study of the MDS Subcommittee of the Chronic.

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Presentation on theme: "Allogeneic Stem Cell Transplantation for Patients Age ≥ 70 Years with Myelodysplastic Syndrome: A Retrospective Study of the MDS Subcommittee of the Chronic."— Presentation transcript:

1 Allogeneic Stem Cell Transplantation for Patients Age ≥ 70 Years with Myelodysplastic Syndrome: A Retrospective Study of the MDS Subcommittee of the Chronic Malignancies Working Party of the EBMT  Silke Heidenreich, Dimitris Ziagkos, Liesbeth C. de Wreede, Anja van Biezen, Jürgen Finke, Uwe Platzbecker, Dietger Niederwieser, Hermann Einsele, Wolfgang Bethge, Michael Schleuning, Dietrich W. Beelen, Johanna Tischer, Arnon Nagler, Bertram Glass, Johan Maertens, Lucrecia Yáñez, Yves Beguin, Heinz Sill, Christof Scheid, Matthias Stelljes, Arnold Ganser, Pierre Zachée, Dominik Selleslag, Theo de Witte, Marie Robin, Nicolaus Kröger  Biology of Blood and Marrow Transplantation  Volume 23, Issue 1, Pages (January 2017) DOI: /j.bbmt Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 HSCT for MDS/sAML patients ages 70 to 79 years. The number of transplantations per year increased over time: , n = 16; , n = 27; , n = 89; , n = 181. Biology of Blood and Marrow Transplantation  , 44-52DOI: ( /j.bbmt ) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Relapse incidence by disease status at transplantation. Disease status “RAEB-t/transformed to AL” had a significant higher risk of relapse, compared with “RAEB/RAEB-1/RAEB-2” (P = .04) but not compared with the other groups. Shaded areas indicate 95% pointwise confidence intervals, and numbers below the x-axis correspond to number of patients at risk for the respective time points. AL indicates acute leukemia. Biology of Blood and Marrow Transplantation  , 44-52DOI: ( /j.bbmt ) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 OS and NRM by KPS and CMV. (A) OS by KPS, P = .01 (B) NRM by KPS, P = .02 (C) OS by CMV, P = .002 (D) NRM by CMV, P = .02. In all plots, shaded areas indicate 95% pointwise confidence intervals, and numbers below the x-axis correspond to number of patients at risk for the respective time points. Biology of Blood and Marrow Transplantation  , 44-52DOI: ( /j.bbmt ) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions


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