Mitochondrial Dysfunction in Atrial Tissue of Patients Developing Postoperative Atrial Fibrillation Jelliffe Jeganathan, MBBS, Rabya Saraf, BA, Feroze.

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Mitochondrial Dysfunction in Atrial Tissue of Patients Developing Postoperative Atrial Fibrillation Jelliffe Jeganathan, MBBS, Rabya Saraf, BA, Feroze Mahmood, MD, Anam Pal, MD, Manoj K. Bhasin, PhD, Thomas Huang, BS, Aaron Mittel, MD, Ziyad Knio, BS, Russell Simons, BS, Kamal Khabbaz, MD, Venkatachalam Senthilnathan, MD, David Liu, MD, Frank Sellke, MD, Robina Matyal, MD The Annals of Thoracic Surgery Volume 104, Issue 5, Pages 1547-1555 (November 2017) DOI: 10.1016/j.athoracsur.2017.04.060 Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Representative immunoblotting and quantitative analysis for the expression of inflammatory markers. Data are reported as mean ± SE (range bars). *p < 0.05; **p < 0.01. (CPB = cardiopulmonary bypass; GAPDH = glyceraldehyde 3-phosphate dehydrogenase; NF-κB = nuclear factor-κB; POAF = postoperative atrial fibrillation; TGF-β = transforming growth factor-β; TNFAIP6 = tumor necrosis factor, α-induced protein 6.) The Annals of Thoracic Surgery 2017 104, 1547-1555DOI: (10.1016/j.athoracsur.2017.04.060) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Representative immunoblotting and quantitative analysis for expression of (A) oxidative stress and fatty acid metabolism proteins and (B) amyloid deposition-related proteins. Data are reported as mean ± SE (range bars). *p < .05; **p < 0.01. (CPB = cardiopulmonary bypass; CPT1 = carnitine palmitoyltransferase I; DHCR24 = 24-dehydrocholesterol reductase; GAPDH = glyceraldehyde 3-phosphate dehydrogenase; MnSOD = manganese superoxide dismutase; PARP1 = poly(adenosine 5′-diphosphate ribose) polymerase 1; PGC-1α = peroxisome proliferator-activated receptor-γ coactivator-1α; POAF = postoperative atrial fibrillation; QPCT = glutaminyl-peptide cyclotransferase; RTN3 = reticulon 3.) The Annals of Thoracic Surgery 2017 104, 1547-1555DOI: (10.1016/j.athoracsur.2017.04.060) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Representative immunoblotting and quantitative analysis for expression of proteins involved in the apoptotic response. Data are reported as mean ± SE (range bars). *p < 0.05; **p < 0.01. (Bcl-2 = B-cell lymphoma 2; CIDEC = cell death inducing DNA fragmentation factor subunit alpha [DFFA] like effector C; CPB = cardiopulmonary bypass; CREB = cyclic adenosine monophosphate-response element binding protein; GAPDH = glyceraldehyde 3-phosphate dehydrogenase; p-Bcl-2 = phosphorylated B-cell lymphoma 2; POAF, postoperative atrial fibrillation.) The Annals of Thoracic Surgery 2017 104, 1547-1555DOI: (10.1016/j.athoracsur.2017.04.060) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Proposed apoptotic pathway after cardiopulmonary bypass-related damage in patients developing postoperative atrial fibrillation. (Bcl-2 = B-cell lymphoma 2; CIDEC = cell death inducing DNA fragmentation factor subunit alpha [DFFA] like effector C; CPT1 = carnitine palmitoyltransferase I; CREB = cyclic adenosine monophosphate-response element binding protein; DHCR24 = 24-dehydrocholesterol reductase; NF-κB = nuclear factor-κB; PARP1 = poly[adenosine 5′-diphosphate ribose] polymerase 1; PGC1α = peroxisome proliferator-activated receptor-γ coactivator-1α; QPCT = glutaminyl-peptide cyclotransferase; RTN3 = reticulon 3; TGF-β = transforming growth factor-β; TNFAIP6 = tumor necrosis factor, α-induced protein 6.) The Annals of Thoracic Surgery 2017 104, 1547-1555DOI: (10.1016/j.athoracsur.2017.04.060) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions