1. Gene Therapy in Cardiac Surgery: Clinical Trials, Challenges, and Perspectives 
Michael G. Katz, MD, PhD, Anthony S. Fargnoli, PhD, Andrew P. Kendle, BS, Roger J. Hajjar, MD, Charles R. Bridges, MD, ScD 
The Annals of Thoracic Surgery 
Volume 101, Issue 6, Pages (June 2016)
DOI: /j.athoracsur
Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

2. Fig 1
Genetic molecular targets in ischemic heart disease. (c-Myc = proto-oncogene protein; DEL-1 = developmental endothelial locus 1; eNOS = endothelial nitric oxide synthase; E2F = transcription factor; FGF = fibroblast growth factor; HGF = hepatocyte growth factor; HIF-1α = hypoxia inducible factor 1α; MAPK = mitogen-activated protein kinase; MMP = matrix metalloproteinases; NFAT = nuclear factor of activated T cells; NO = nitric oxide; Oral 1/3 = ORAI calcium release-activated calcium modulator 1/3; SERCA2a = sarcoplasmic reticulum adenosine triphosphatase isoform 2a; SMC = smooth muscle cells; STIM-1 = stromal interaction molecule-1; TIMP = tissue inhibitor metalloproteinases; VEGF = vascular endothelial growth factor.)
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

3. Fig 2
Genetic molecular targets in heart failure. (Akt = serine/threonine kinase; βARKct = βAR kinase carboxy terminus; Bcl-2 = B-cell lymphoma; GRK = G-protein-coupled receptor kinase; HO-1 = heme oxygenase enzyme-1; HSP = heat shock protein; P13 = phosphoinositide 3-kinase; ROS = reactive oxidative species; S100A1 = S100 calcium-binding protein A1; SDF-1 = stromal-derived factor 1; SERCA2a = sarcoplasmic reticulum adenosine triphosphatase isoform 2a; TGF-β = transforming growth factor; TNF = tumor necrosis factor.)
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions