Toll Signaling in Flies and Mammals: Two Sorts of MyD88

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Toll Signaling in Flies and Mammals: Two Sorts of MyD88 Akira Goto, Jean-Luc Imler  Immunity  Volume 36, Issue 4, Pages 555-557 (April 2012) DOI: 10.1016/j.immuni.2012.04.001 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Targeting of dMyD88 to the Plasma Membrane through Its C-Terminal Extension Is Important for Toll Signaling in Drosophila In mammals (left), TIRAP recruits MyD88 to the plasma membrane to mediate TLR4 signaling, whereas in flies (right) the C-terminal extension of dMyD88 enables it to directly interact with PI(4,5)P2, which is predominantly found in the plasma membrane. Immunity 2012 36, 555-557DOI: (10.1016/j.immuni.2012.04.001) Copyright © 2012 Elsevier Inc. Terms and Conditions

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