Figure S3. in vivo Study of ABT-263 or SAR in the RS4;11 model in mice

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Figure S3. in vivo Study of ABT-263 or SAR405838 in the RS4;11 model in mice. A, Immunoblotting of BAX and BAK in sublines isolated from RS4;11 xenografts treated with ABT-263 first followed by a second treatment with either ABT-263 or SAR405838. B, Immunoblotting of BAX and BAK in sublines isolated from RS4;11 xenografts treated with SAR405838 first followed by a second treatment with either ABT-263 or SAR405838. C, Antitumor activity of RS4;11 xenografts treated with ABT-263 for 21 days at 100 mg/kg orally (top) and body weight of mice during second round of treatment (bottom). D, Antitumor activity of RS4;11 xenografts treated with SAR405838 for 21 days at 100 mg/kg orally (top) and body weight of mice during second round of treatment (bottom). A 30R A1M A2M A4M A7M A3A A5A B A#M 1st: 100 mg/kg ABT-263 2nd : 100 mg/kg SAR RS4;11 30L 30R M16M M7A M9A M13A M14A M16M 1st : 100 mg/kg SAR 2nd : 200 mg/kg SAR BAX BAX BAK A#A 1st: 100 mg/kg ABT-263 2nd : 150 mg/kg ABT-263 BAK M#A 1st : 100 mg/kg SAR 2nd : 100 mg/kg ABT-263 GAPDH GAPDH C D