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Determination of MTD for romidepsin and pralatrexate and associated antitumor activity. Determination of MTD for romidepsin and pralatrexate and associated.

Published byBudi Pranoto Modified over 4 years ago

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Presentation on theme: "Determination of MTD for romidepsin and pralatrexate and associated antitumor activity. Determination of MTD for romidepsin and pralatrexate and associated."— Presentation transcript:

1 Determination of MTD for romidepsin and pralatrexate and associated antitumor activity.
Determination of MTD for romidepsin and pralatrexate and associated antitumor activity. In vivo surface bioluminescence acquired images of H9 human TCL xenograft tumors in mice with corresponding mean BLI response to i.p. treatment with: romidepsin (1.2 mg/kg dose), showed minimal effect on tumor reduction but was well tolerated (A), pralatrexate (30 mg/kg dose), demonstrated marked antitumor activity but associated with high toxicity (B), romidepsin (2 mg/kg dose), exhibited modest activity but associated with toxicity (C), pralatrexate (15 mg/kg dose), revealed minimal antitumor activity but was well tolerated (D). All drugs were administered on days 1, 4, 8, and 11. Salvia Jain et al. Clin Cancer Res 2015;21: ©2015 by American Association for Cancer Research

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