Volume 9, Issue 2, Pages (February 2002)

Slides:

Advertisements

Similar presentations

Volume 9, Issue 2, Pages (February 2002)

Advertisements

Finn Werner, Robert O.J Weinzierl Molecular Cell

Cell signaling and cancer

Junwei Shi, Christopher R. Vakoc Molecular Cell

Saving the Ends for Last: The Role of Pol μ in DNA End Joining

Structural Basis for the Specific Recognition of Methylated Histone H3 Lysine 4 by the WD-40 Protein WDR5 Zhifu Han, Lan Guo, Huayi Wang, Yue Shen, Xing.

Smads “Freeze” When They Ski

PAF Makes It EZ(H2) for β-Catenin Transactivation

Eukaryotic Transcription Activation: Right on Target

Ubiquitin Recognition by the Human TSG101 Protein

Signaling by Transmembrane Proteins Shifts Gears

Function of the APC 1.Reducing the levels of cytoplasmic bcatenin by binding to Axin. 2. Nuclear APC binding to beta-catenin, and then inducing its nuclear.

The C. elegans SYS-1 Protein Is a Bona Fide β-Catenin

Volume 19, Issue 2, Pages (February 2011)

Transcription Initiation at Its Most Basic Level

Volume 28, Issue 6, Pages (December 2007)

A Million Peptide Motifs for the Molecular Biologist

Volume 98, Issue 6, Pages (September 1999)

The Chromatin Signaling Pathway: Diverse Mechanisms of Recruitment of Histone- Modifying Enzymes and Varied Biological Outcomes Edwin Smith, Ali Shilatifard

Volume 25, Issue 4, Pages (February 2007)

Splitting p63 The American Journal of Human Genetics

Ann Hochschild, Simon L Dove Cell

Hongwei Wu, Mark W. Maciejewski, Sachiko Takebe, Stephen M. King

The Bare Lymphocyte Syndrome: Molecular Clues to the Transcriptional Regulation of Major Histocompatibility Complex Class II Genes Angela DeSandro, Uma.

Shifted from Wnt to Hedgehog Signaling Pathways

Structural Basis for Protein Recognition by B30.2/SPRY Domains

Smad proteins and transforming growth factor-β signaling

Structure, Exchange Determinants, and Family-Wide Rab Specificity of the Tandem Helical Bundle and Vps9 Domains of Rabex-5 Anna Delprato, Eric Merithew,

The Role of PML in Tumor Suppression

Chromatin structure: Linking structure to function with histone H1

Crystal Structure of Carnitine Acetyltransferase and Implications for the Catalytic Mechanism and Fatty Acid Transport Gerwald Jogl, Liang Tong Cell

Crystal Structure of the p53 Core Domain Bound to a Full Consensus Site as a Self- Assembled Tetramer Yongheng Chen, Raja Dey, Lin Chen Structure Volume.

A Versatile Transcriptional Effector of Wingless Signaling

A CRISPR Approach to Gene Targeting

PARP Goes Transcription

ICAT Inhibits β-Catenin Binding to Tcf/Lef-Family Transcription Factors and the General Coactivator p300 Using Independent Structural Modules Danette.

Volume 92, Issue 1, Pages 1-4 (January 1998)

What Does It Take to Bind CAR?

The LDL Receptor Gene Family

Volume 10, Issue 6, Pages (June 2002)

Repression Cell Volume 99, Issue 5, Pages (November 1999)

Alessandro Bonetti, Piero Carninci Molecular Cell

The Structure of the β-Catenin/E-Cadherin Complex and the Molecular Basis of Diverse Ligand Recognition by β-Catenin Andrew H. Huber, William I. Weis

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

The Many Interfaces of Mre11

Jeffrey J. Wilson, Rhett A. Kovall Cell

Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 Phosphopeptide

Fingering the Ends Cell Volume 113, Issue 5, Pages (May 2003)

Factors that Mediate and Modulate Androgen Action

Enhancer Malfunction in Cancer

Shifty Ciliates Lawrence A. Klobutcher, Philip J. Farabaugh Cell

Shared Principles in NF-κB Signaling

Signaling to Chromatin through Histone Modifications

Polymerases and the Replisome: Machines within Machines

Volume 87, Issue 5, Pages (November 1996)

Volume 2, Issue 1, Pages 1-4 (January 1994)

Thomas A Graham, Wilson K Clements, David Kimelman, Wenqing Xu

Crystal Structure of a Smad MH1 Domain Bound to DNA

Volume 119, Issue 4, Pages (October 2000)

Bacillus subtilis Glutamine Synthetase Controls Gene Expression through a Protein- Protein Interaction with Transcription Factor TnrA Lewis V Wray, Jill.

Chromatin Repressive Complexes in Stem Cells, Development, and Cancer

Guilty as charged Cancer Cell

Structure of the Histone Acetyltransferase Hat1

Adam T. McGeoch, Stephen D. Bell Cell

Hinrich Gronemeyer, Arthur Zelent Cancer Cell

TGF-β Pathway Inhibition Signals New Hope for Fanconi Anemia

Making Cancer Quiescent: SPDEF De-Cycles Beta-Catenin

Volume 7, Issue 6, Pages (June 2001)

Tenets of PTEN Tumor Suppression

Volume 13, Issue 14, Pages (July 2003)

Presentation transcript:

Volume 9, Issue 2, Pages 213-224 (February 2002) CtBP, an Unconventional Transcriptional Corepressor in Development and Oncogenesis G Chinnadurai Molecular Cell Volume 9, Issue 2, Pages 213-224 (February 2002) DOI: 10.1016/S1097-2765(02)00443-4

Figure 1 Domain Structure and Functional Map of hCtBP1 The regions of highest homology with 2-hydroxy acid dehydrogenases are shown in red. The putative catalytic His residue is indicated. The regions required for mediating transcriptional repression of hCtBP1 and binding to the PXDLS motif are based on Koipally and Georgopoulos (2000). The dCtBP sequences required for repression (indicated by the thicker line) and transcriptional activation in mammalian cells are based on Phippen et al. (2000). The coordinates indicate hCtBP1 sequences that correspond to dCtBP. The sequences required for homodimerization (CtBP2) are based on Sewalt et al. (1999). For detailed sequence alignments with various CtBPs and dehydrogenases, see Turner and Crossley, 2001. Molecular Cell 2002 9, 213-224DOI: (10.1016/S1097-2765(02)00443-4)

Figure 2 CtBP Corepressor Complex CtBP associates with DNA binding transcription factors either directly or through other proteins such as CtIP, RIP140, or class II HDACs as well as MIRT. Molecular Cell 2002 9, 213-224DOI: (10.1016/S1097-2765(02)00443-4)

Figure 3 Modulation of E1A Activities by CtBP Three different models that may explain the effect of CtBP on E1A-mediated oncogenic transformation are presented. See the text for further details. Molecular Cell 2002 9, 213-224DOI: (10.1016/S1097-2765(02)00443-4)

Figure 4 Modulation of Wnt Signaling during Oncogenesis by CtBP The (A)9 repeat frequently mutated in gastrointestinal tumors with MSI is indicated. Potential acetylation of the Lys residues adjacent to the CtBP binding motifs or frame shift mutations (due to deletion of an A residue) within the A(9) repeat may abolish CtBP interaction and facilitate trans-activation by β-catenin and CBP in tumor cells. Molecular Cell 2002 9, 213-224DOI: (10.1016/S1097-2765(02)00443-4)