Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail

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Presentation transcript:

Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail Paul S. Knoepfler Cell Stem Cell Volume 2, Issue 1, Pages 18-21 (January 2008) DOI: 10.1016/j.stem.2007.12.004 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Models of Myc Function in iPS Cell Formation Models of three potential mechanisms by which Myc induces iPS cell formation: self-renewal through cell-cycle changes, chromatin reprogramming that possibly influences differentiation or the subsequent activity of the other three factors, and selection of a rare permissive cell. Also a combination model is presented at the bottom incorporating aspects of the individual models into a step-wise process. Cell Stem Cell 2008 2, 18-21DOI: (10.1016/j.stem.2007.12.004) Copyright © 2008 Elsevier Inc. Terms and Conditions