Copyright © 2004 American Medical Association. All rights reserved. From: Pramipexole vs Levodopa as Initial Treatment for Parkinson DiseaseA 4-Year Randomized Controlled Trial Arch Neurol. 2004;61(7):1044-1053. doi:10.1001/archneur.61.7.1044 Figure Legend: Patient flow. PD indicates Parkinson disease. Date of download: 11/27/2018 Copyright © 2004 American Medical Association. All rights reserved.

Copyright © 2004 American Medical Association. All rights reserved. From: Pramipexole vs Levodopa as Initial Treatment for Parkinson DiseaseA 4-Year Randomized Controlled Trial Arch Neurol. 2004;61(7):1044-1053. doi:10.1001/archneur.61.7.1044 Figure Legend: Cumulative probability of reaching the first dopaminergic complication (A) and the individual complications wearing off (B), dyskinesias (C), and freezing (D) by treatment assignment. First dopaminergic complication is defined as the first occurrence of wearing off, dyskinesias, or on-off fluctuations. Date of download: 11/27/2018 Copyright © 2004 American Medical Association. All rights reserved.

Copyright © 2004 American Medical Association. All rights reserved. From: Pramipexole vs Levodopa as Initial Treatment for Parkinson DiseaseA 4-Year Randomized Controlled Trial Arch Neurol. 2004;61(7):1044-1053. doi:10.1001/archneur.61.7.1044 Figure Legend: Mean (SE) total (parts I + II + III), motor, activities of daily living, and mental Unified Parkinson's Disease Rating Scale scores during the course of the trial by treatment assignment. Date of download: 11/27/2018 Copyright © 2004 American Medical Association. All rights reserved.