1. Date of download: 7/9/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Around-the-Clock, Controlled-Release Oxycodone Therapy for Osteoarthritis-Related Pain: Placebo- Controlled Trial and Long-term Evaluation Arch Intern Med. 2000;160(6):853-860. doi:10.1001/archinte.160.6.853 Disposition of patients enrolled in the double-blind, placebo-controlled trial of controlled-release (CR) oxycodone, 10 and 20 mg, every 12 hours. Figure Legend:

2. Date of download: 7/9/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Around-the-Clock, Controlled-Release Oxycodone Therapy for Osteoarthritis-Related Pain: Placebo- Controlled Trial and Long-term Evaluation Arch Intern Med. 2000;160(6):853-860. doi:10.1001/archinte.160.6.853 Daily mean pain intensity (0 indicates none; 1, slight; 2, moderate; and 3, severe) during 14-day double-blind treatment. CR indicates controlled release. Error bars represent SE. Figure Legend:

3. Date of download: 7/9/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Around-the-Clock, Controlled-Release Oxycodone Therapy for Osteoarthritis-Related Pain: Placebo- Controlled Trial and Long-term Evaluation Arch Intern Med. 2000;160(6):853-860. doi:10.1001/archinte.160.6.853 Mean improvement from baseline in mitigating interference of pain with lifestyle (using the Brief Pain Inventory and a numerical scale from 0-10). CR indicates controlled release. Asterisk indicates P<.05 better than placebo. Figure Legend:

4. Date of download: 7/9/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Around-the-Clock, Controlled-Release Oxycodone Therapy for Osteoarthritis-Related Pain: Placebo- Controlled Trial and Long-term Evaluation Arch Intern Med. 2000;160(6):853-860. doi:10.1001/archinte.160.6.853 Daily dose of controlled-release oxycodone administered and pain intensity (0 indicates none; 1, slight; 2, moderate; and 3, severe) during the long-term trial. The black triangle indicates the baseline pain intensity lead-in. Error bars represent SE. Figure Legend:

5. Date of download: 7/9/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Around-the-Clock, Controlled-Release Oxycodone Therapy for Osteoarthritis-Related Pain: Placebo- Controlled Trial and Long-term Evaluation Arch Intern Med. 2000;160(6):853-860. doi:10.1001/archinte.160.6.853 Mean duration ratio (calculated as the number of days the patient experienced the adverse event divided by number of days the patient was treated with controlled-release oxycodone, expressed as a percentage) of 4 opioid side effects during the long-term trial. Error bars represent SE. Figure Legend: