Why Is There so Much CD45 on T Cells?

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Why Is There so Much CD45 on T Cells? Rose Zamoyska Immunity Volume 27, Issue 3, Pages 421-423 (September 2007) DOI: 10.1016/j.immuni.2007.08.009 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 Regulation of Lck Activity by the Opposing Actions of Kinases and Phosphases The regulatory Tyr (Y505) of Lck is phosphorylated by the kinase Csk, which maintains Lck in an inactive conformation. The dephosphorylation of Y505 by CD45 in resting T cells sustains a pool of basally active Lck. Upon T cell stimulation, this pool of Lck auto- or transphosphorylates the Tyr residue in the kinase domain (Y394), which in turn enhances Lck kinase activity. CD45 can also dephosphorylate Y394, returning Lck to the basally active state. Immunity 2007 27, 421-423DOI: (10.1016/j.immuni.2007.08.009) Copyright © 2007 Elsevier Inc. Terms and Conditions