Adoptive Immunotherapy Against Allogeneic Kidney Grafts in Dogs with Stable Hematopoietic Trichimerism Scott S. Graves, William J. Hogan, Christian Kuhr,

Slides:

Advertisements

Similar presentations

Evidence of B Cell Immune Responses to Acute Lymphoblastic Leukemia in Murine Allogeneic Hematopoietic Stem Cell Transplantation Recipients Treated with.

Advertisements

Acute Kidney Injury and the Risk of Mortality in Children Undergoing Hematopoietic Stem Cell Transplantation Sarah J. Kizilbash, Clifford E. Kashtan,

David D. Yuh, MD, Kimberly L. Gandy, MD, Bruce A

Reduced Graft-versus-Host Disease in C3-Deficient Mice Is Associated with Decreased Donor Th1/Th17 Differentiation Qing Ma, Dan Li, Roza Nurieva, Rebecca.

Th2 Cell Therapy of Established Acute Graft-Versus-Host Disease Requires IL-4 and IL- 10 and Is Abrogated by IL-2 or Host-Type Antigen-Presenting Cells

George E. Georges, Vladimir Lesnikov, Szczepan W

Adoptive immunotherapy in canine mixed chimeras after nonmyeloablative hematopoietic cell transplantation by George E. Georges, Rainer Storb, Jennifer.

T-Cell Receptor Vα Usage by Effector CD4+Vβ11+ T Cells Mediating Graft-versus-Host Disease Directed to Minor Histocompatibility Antigens Christine G.

Chimerism-Based Pre-Emptive Immunotherapy with Fast Withdrawal of Immunosuppression and Donor Lymphocyte Infusions after Allogeneic Stem Cell Transplantation.

A Canine Model of Chronic Graft-versus-Host Disease

Allogeneic Stem Cell Transplantation in Myelofibrosis

Busulfan, Fludarabine, and Alemtuzumab As a Reduced Toxicity Regimen for Children with Malignant and Nonmalignant Diseases Improves Engraftment and Graft-versus-

Impact of Donor Type on Outcome after Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia Scott R. Solomon, Connie A. Sizemore, Xu Zhang,

Postgrafting immunosuppression with sirolimus and cyclosporine facilitates stable mixed hematopoietic chimerism in dogs given sublethal total body irradiation.

Purification of CD4+ T Cells for Adoptive Immunotherapy after Allogeneic Hematopoietic Stem Cell Transplantation Evgeny Klyuchnikov, Andreas Sputtek,

Keratinocyte Dysplasia in Hematopoietic Stem Cell Transplantation Recipients in the Day-28-to-84 Posttransplantation Period Ning Li, Katherine A. Guthrie,

Characterizing Donor-Derived Cells in Nonhematopoietic Tissue

Genital Chronic Graft-versus-Host Disease in Females: A Cross-Sectional Study Eva Smith Knutsson, Yvonne Björk, Anna-Karin Broman, Lotti Helström, Anne-Marie.

Survival and Function of MiHA Epitope-Specific Host CD8 TM Cells Following Ablative Conditioning and HCT Alwi M. Shatry, Derry C. Roopenian, Robert B.

Detection of Microchimerism by Minor Histocompatibility Antigen HA-1 Allele-Specific Nested Polymerase Chain Reaction Brigitte Wieles, Jos Pool, Richard.

Evidence of a Graft-versus-Hodgkin Lymphoma Effect in the Setting of Extensive Bone Marrow Involvement Paolo Anderlini, MD Biology of Blood and Marrow.

Leukemia Lineage-Specific Chimerism Analysis and Molecular Monitoring Improve Outcome of Donor Lymphocyte Infusions Darius Sairafi, Mats Remberger, Michael.

Anti-Inducible Costimulator Monoclonal Antibody Treatment of Canine Chronic Graft- versus-Host Disease Scott S. Graves, Maura H. Parker, Diane Stone,

Donor-to-Recipient ABO Mismatch Does Not Impact Outcomes of Allogeneic Hematopoietic Cell Transplantation Regardless of Graft Source Sharat Damodar,

Lisa A. Palmer, George E. Sale, John I

A Phase I/II Study of Chemotherapy Followed by Donor Lymphocyte Infusion plus Interleukin-2 for Relapsed Acute Leukemia after Allogeneic Hematopoietic.

Mesenchymal Stromal Cells Fail to Prevent Acute Graft-versus-Host Disease and Graft Rejection after Dog Leukocyte Antigen-Haploidentical Bone Marrow Transplantation

Donor Lymphocyte Infusion–Mediated Graft-versus-Host Responses in a Preclinical Swine Model of Haploidentical Hematopoietic Cell Transplantation Raimon.

Th2 Cell Therapy of Established Acute Graft-Versus-Host Disease Requires IL-4 and IL- 10 and Is Abrogated by IL-2 or Host-Type Antigen-Presenting Cells

A Radio-Resistant Perforin-Expressing Lymphoid Population Controls Allogeneic T Cell Engraftment, Activation, and Onset of Graft-versus-Host Disease in.

Improvement of Pulmonary Function with Imatinib Mesylate in Bronchiolitis Obliterans Following Allogeneic Hematopoietic Cell Transplantation Navneet.

Sequential Intensified Conditioning and Tapering of Prophylactic Immunosuppressants for Graft-versus-Host Disease in Allogeneic Hematopoietic Stem Cell.

Nonmyeloablative Unrelated Donor Hematopoietic Cell Transplantation to Treat Patients with Poor-Risk, Relapsed, or Refractory Multiple Myeloma George.

Nasal Epithelial Cells of Donor Origin after Allogeneic Hematopoietic Cell Transplantation are Generated at a Faster Rate in the First 3 Months Compared.

In Situ Activation and Expansion of Host Tregs: A New Approach to Enhance Donor Chimerism and Stable Engraftment in Major Histocompatibility Complex-Matched.

B Cells and Transplantation: An Educational Resource

Low Radiation Dose and Low Cell Dose Increase the Risk of Graft Rejection in a Canine Hematopoietic Stem Cell Transplantation Model Sandra Lange, Anne.

Paul A. Hoffmeister, Sangeeta R. Hingorani, Barry E. Storer, K

Pulmonary Cytolytic Thrombi after Allogeneic Hematopoietic Cell Transplantation: A Further Histologic Description Antoinette Peters, J. Carlos Manivel,

Allogeneic Hematopoietic Stem Cell Transplantation in Adult Acute Lymphocytic Leukemia: Impact of Donor Source on Survival Priya Kumar, Todd E. Defor,

A Phase I/II Study of Mycophenolate Mofetil in Combination with Cyclosporine for Prophylaxis of Acute Graft-versus-Host Disease after Myeloablative Conditioning.

Allogeneic Transplantation for Pediatric Acute Lymphoblastic Leukemia: The Emerging Role of Peritransplantation Minimal Residual Disease/Chimerism Monitoring.

Pharmacokinetic Evaluation of the Drug Interaction between Intravenous Itraconazole and Intravenous Tacrolimus or Intravenous Cyclosporin A in Allogeneic.

Sabina Kersting, Ronald J. Hené, Hein A. Koomans, Leo F. Verdonck

Persistence of host dendritic cells after transplantation is associated with graft-versus- host disease Geoffrey W. Chan, Gullu Gorgun, Kenneth B. Miller,

Shigeo Fuji, Hermann Einsele, Bipin N. Savani, Markus Kapp

Impact of Donor and Recipient Sex and Parity on Outcomes of HLA-Identical Sibling Allogeneic Hematopoietic Stem Cell Transplantation Alison W. Loren,

Acute Kidney Injury and the Risk of Mortality in Children Undergoing Hematopoietic Stem Cell Transplantation Sarah J. Kizilbash, Clifford E. Kashtan,

NCI, NHLBI/PBMTC First International Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation: Health-Related Quality of Life, Functional,

Brile Chung, Eric Dudl, Akira Toyama, Lora Barsky, Kenneth I. Weinberg

The Hematopoietic Cell Transplant Pharmacist: Roles, Responsibilities, and Recommendations from the ASBMT Pharmacy Special Interest Group Amber B. Clemmons,

Regression Models for Hazard Rates Versus Cumulative Incidence Probabilities in Hematopoietic Cell Transplantation Data Brent R. Logan, Mei-Jie Zhang,

Lack of correlation between an assay used to determine early marrow allograft rejection and long-term chimerism after murine allogeneic bone marrow transplantation:

Gerard Socié, K. Scott Baker, Smita Bhatia

What is quality in a transplant program?

Salvage Allogeneic Hematopoietic Cell Transplantation with Fludarabine and Low-Dose Total Body Irradiation after Rejection of First Allografts Boglarka.

Chimeric Antigen Receptor–Modified T Cells: Clinical Translation in Stem Cell Transplantation and Beyond Stanley R. Riddell, Michael C. Jensen, Carl.

Blood and Marrow Transplant Handbook

Pharmacological Immunosuppression Reduces But Does Not Eliminate the Need for Total-Body Irradiation in Nonmyeloablative Conditioning Regimens for Hematopoietic.

Reversal of Low Donor Chimerism after Hematopoietic Cell Transplantation Using Pentostatin and Donor Lymphocyte Infusion: A Prospective Phase II Multicenter.

Mammen Chandy Biology of Blood and Marrow Transplantation

Volume 74, Issue 9, Pages (November 2008)

Reduced Intensity Conditioning for Allogeneic Hematopoietic Cell Transplantation: Current Perspectives Brenda M. Sandmaier, Stephen Mackinnon, Richard.

Frédéric Baron, Rainer Storb

Prospective Monitoring of Tumor Necrosis Factor α and Interferon γ to Predict the Onset of Acute and Chronic Graft-versus-Host Disease after Allogeneic.

Hematopoietic cell transplantation from related and unrelated donors after minimal conditioning as a curative treatment modality for severe paroxysmal.

What Role Is There for Antithymocyte Globulin in Allogeneic Nonmyeloablative Canine Hematopoietic Cell Transplantation? Razvan Diaconescu, Marie-Térèse.

Outcomes among Patients with Recurrent High-Risk Hematologic Malignancies after Allogeneic Hematopoietic Cell Transplantation Marco Mielcarek, Barry.

Futility of Relapsed Diffuse Large B Cell Lymphoma Transplantation?

Andrew R. Rezvani, Barry E. Storer, Katherine A. Guthrie, H

Presentation transcript:

Adoptive Immunotherapy Against Allogeneic Kidney Grafts in Dogs with Stable Hematopoietic Trichimerism Scott S. Graves, William J. Hogan, Christian Kuhr, Razvan Diaconescu, Michael Harkey, George E. Sale, Brad Stone, George E. Georges, Rainer Storb Biology of Blood and Marrow Transplantation Volume 14, Issue 11, Pages 1201-1208 (November 2008) DOI: 10.1016/j.bbmt.2008.08.005 Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 A, Schema for generating trichimeric marrow recipients and kidney transplant rejection. After 2 Gy TBI (1), marrow from 2 DLA-identical donors was simultaneously injected into the recipient (2). Postgrafting immunosuppression with CSP and MMF followed for 35 and 28 days, respectively (3). B, After stable trichimerism was established, a kidney was transplanted from donor 2 into the recipient (4). Once stable kidney engraftment was verified, donor 1 was sensitized against minor H antigens of donor 2 with 3 PBMC injections (5). After DLI from sensitized donor 1 into the trichimeric recipient (6), the dogs were monitored for a shift in donor chimerism, GVHD, and kidney graft rejection (7). Biology of Blood and Marrow Transplantation 2008 14, 1201-1208DOI: (10.1016/j.bbmt.2008.08.005) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Kidney histology of dogs G513, G362, and G643 before sensitized DLI and at necropsy. Biopsies of kidney allografts were done using a percutaneous biopsy needle within 1 week before DLI (left column); sections of both allografted (middle column) and native kidneys (right column) were collected at necropsy. Tissues were fixed in 10% buffered formalin, fixed, stained with hematoxylin and eosin, and photographed at 100× magnification. Biology of Blood and Marrow Transplantation 2008 14, 1201-1208DOI: (10.1016/j.bbmt.2008.08.005) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Granulocyte (A) and PBMC (B) chimerism in dog G643 before and after receipt of sensitized DLI from donor 1. Stable long-term granulocyte and mononuclear cell trichimerism in the HCT recipient (♦), donor 1 (■) and donor 2 (▴) was interrupted after an infusion of sensitized lymphocytes from donor 1 at week 44. Data points were obtained by VNTR PCR analysis. Biology of Blood and Marrow Transplantation 2008 14, 1201-1208DOI: (10.1016/j.bbmt.2008.08.005) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Histology of skin, liver and gut of dogs G513, G362, and G643 at necropsy. Tissues were fixed in 10% buffered formalin, sectioned, stained with hematoxylin and eosin, and photographed at 250× magnification. Mononuclear cell infiltrates (→) and apoptotic epithelial cells or damaged obliterated duct structures (○) are indicated. Biology of Blood and Marrow Transplantation 2008 14, 1201-1208DOI: (10.1016/j.bbmt.2008.08.005) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions