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Low Radiation Dose and Low Cell Dose Increase the Risk of Graft Rejection in a Canine Hematopoietic Stem Cell Transplantation Model  Sandra Lange, Anne.

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Presentation on theme: "Low Radiation Dose and Low Cell Dose Increase the Risk of Graft Rejection in a Canine Hematopoietic Stem Cell Transplantation Model  Sandra Lange, Anne."— Presentation transcript:

1 Low Radiation Dose and Low Cell Dose Increase the Risk of Graft Rejection in a Canine Hematopoietic Stem Cell Transplantation Model  Sandra Lange, Anne Steder, Änne Glass, Doreen Killian, Susanne Wittmann, Christoph Machka, Juliane Werner, Stephanie Schäfer, Catrin Roolf, Christian Junghanss  Biology of Blood and Marrow Transplantation  Volume 22, Issue 4, Pages (April 2016) DOI: /j.bbmt Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Kaplan-Meier curves of cumulative graft survival according to the potential pretransplantation risk factors radiation dose, type of immunosuppression, and total nucleated cell dose. CSA, cyclosporine A; MMF, mycophenolate mofetil; RAD, everolimus. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Kaplan-Meier curves of cumulative graft survival according to the predictive parameters donor PBMCs and granulocyte chimerism at day +28 after HSCT. Dogs are categorized on the basis of PBMC chimerism, </≥30%, and granulocyte chimerism, </≥70%. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions


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