Vasoconstrictor Therapy for the Hepatorenal Syndrome

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Vasoconstrictor Therapy for the Hepatorenal Syndrome Joseph K. Lim, Roberto J. Groszmann Gastroenterology Volume 134, Issue 5, Pages 1608-1611 (May 2008) DOI: 10.1053/j.gastro.2008.03.034 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 A, Beneficial effects of vasoconstriction. In liver cirrhosis, progressive splanchnic vasodilatation leads to renal vasoconstriction. Splanchnic and systemic vasoconstrictors increases renal perfusion pressure and flow with the consequent increase in the excretion of sodium and water and improvement of renal function.6,7. B, On the contrary reversal of systemic vasodilatation induces detrimental effects on cardiac function6,7 and may aggravate brain edema in patients with liver failure, although results are mixed.8,9 The reports in the pulmonary circulation are also mixed.10 Gastroenterology 2008 134, 1608-1611DOI: (10.1053/j.gastro.2008.03.034) Copyright © 2008 AGA Institute Terms and Conditions