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Renal dysfunction in cirrhosis is not just a vasomotor nephropathy

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Presentation on theme: "Renal dysfunction in cirrhosis is not just a vasomotor nephropathy"— Presentation transcript:

1 Renal dysfunction in cirrhosis is not just a vasomotor nephropathy
Danielle Adebayo, Vincenzo Morabito, Andrew Davenport, Rajiv Jalan  Kidney International  Volume 87, Issue 3, Pages (March 2015) DOI: /ki Copyright © 2015 International Society of Nephrology Terms and Conditions

2 Figure 1 The vasodilatation hypothesis of hepatorenal syndrome. In cirrhosis, portal hypertension leads to splanchnic and systemic vasodilatation, which results in a decrease in effective arterial volume. This in turn leads to the activation of vasoconstrictor systems leading to a reduction in renal blood flow. An impairment of cardiac function (cirrhotic cardiomyopathy) and abnormal renal blood flow autoregulation further contributes to renal hypoperfusion, resulting in HRS. (Adapted from Wong et al.13). Kidney International  , DOI: ( /ki ) Copyright © 2015 International Society of Nephrology Terms and Conditions

3 Figure 2 Renal dysfunction in cirrhosis. A Figure depicting our current understanding on the main features distinguishing between the hypovolemia, hepatorenal syndrome, and renal dysfunction associated with inflammation and infection. Kidney International  , DOI: ( /ki ) Copyright © 2015 International Society of Nephrology Terms and Conditions


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