Giant ragweed specific immunotherapy is not effective in a proportion of patients sensitized to short ragweed: Analysis of the allergenic differences.

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Giant ragweed specific immunotherapy is not effective in a proportion of patients sensitized to short ragweed: Analysis of the allergenic differences between short and giant ragweed Riccardo Asero, MD, Bernhard Weber, PhD, Gianni Mistrello, BSc, Stefano Amato, BSc, Enzo Madonini, MD, Oliver Cromwell, PhD Journal of Allergy and Clinical Immunology Volume 116, Issue 5, Pages 1036-1041 (November 2005) DOI: 10.1016/j.jaci.2005.08.019 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Short ragweed immunoblot analysis with sera from all 16 patients included in the cross-sectional part of the study. IgE reactivity to several allergens at different molecular weights can be observed, although reactivity at about 43 kd (Amb a 1) is virtually always present. No reactivity at 5 kd (Amb a 5) can be appreciated. IT, Immunotherapy. Journal of Allergy and Clinical Immunology 2005 116, 1036-1041DOI: (10.1016/j.jaci.2005.08.019) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Inhibition of IgE antibody binding in a short ragweed immunoblot with sera from 5 subjects who had not undergone immunotherapy. Binding to short ragweed on the immunoblot was inhibited with (1) 0.9 mg giant ragweed extract, (2) 0.45 mg giant ragweed extract, (3) 0.23 mg giant ragweed extract, (4) no inhibitor, and (5) 1.0 mg short ragweed extract. Journal of Allergy and Clinical Immunology 2005 116, 1036-1041DOI: (10.1016/j.jaci.2005.08.019) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Inhibition of IgE antibody binding in a short ragweed immunoblot with sera from 4 subjects who had undergone immunotherapy with a giant ragweed preparation. Binding to short ragweed on the immunoblot was inhibited with (1) 0.9 mg giant ragweed extract, (2) 0.45 mg giant ragweed extract, (3) 0.23 mg giant ragweed extract, (4) no inhibitor, and (5) 1.0 mg short ragweed extract. Journal of Allergy and Clinical Immunology 2005 116, 1036-1041DOI: (10.1016/j.jaci.2005.08.019) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 4 Inhibition of IgE antibody binding in a short ragweed immunoblot with sera from 6 subjects who were treated first with a giant ragweed preparation and subsequently with short ragweed immunotherapy. Binding to short ragweed on the immunoblot was inhibited with (1) 0.9 mg giant ragweed extract, (2) 0.45 mg giant ragweed extract, (3) 0.23 mg giant ragweed extract, (4) no inhibitor, and (5) 1.0 mg short ragweed extract. Journal of Allergy and Clinical Immunology 2005 116, 1036-1041DOI: (10.1016/j.jaci.2005.08.019) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 5 Ragweed specific IgE reactivity of serum from a short ragweed skin test–positive/giant ragweed skin test–negative subject. IgE reactivity of patient's serum (lane 1) and of a normal serum (lane 2) to Ambrosia elatior (short ragweed) pollen; IgE reactivity of patient's serum (lane 3) and a normal serum (lane 4) to Ambrosia trifida (giant ragweed) pollen. Journal of Allergy and Clinical Immunology 2005 116, 1036-1041DOI: (10.1016/j.jaci.2005.08.019) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions