Shoshana H. Ballew, PhD, Yan Chen, BS, Natalie R. Daya, MPH, Job G

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Frailty, Kidney Function, and Polypharmacy: The Atherosclerosis Risk in Communities (ARIC) Study Shoshana H. Ballew, PhD, Yan Chen, BS, Natalie R. Daya, MPH, Job G. Godino, PhD, B. Gwen Windham, MD, MHS, Mara McAdams- DeMarco, PhD, Josef Coresh, MD, PhD, Elizabeth Selvin, PhD, Morgan E. Grams, MD, PhD American Journal of Kidney Diseases Volume 69, Issue 2, Pages 228-236 (February 2017) DOI: 10.1053/j.ajkd.2016.08.034 Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Adjusted prevalence ratios for frailty status by estimated glomerular filtration rate (eGFR). Prevalence ratios adjusted for age, sex, race-center, education, smoking status, alcohol consumption, body mass index, systolic blood pressure, anemia (hemoglobin), inflammation (C-reactive protein), cardiovascular disease (history of coronary heart disease, peripheral artery disease, heart failure, and stroke), diabetes, hypertension medications use, statin medication use), and albumin-creatinine ratio (log-transformed). Abbreviations: CI, confidence interval; eGFRcr, creatinine-based estimated glomerular filtration rate; eGFRcys, cystatin C−based estimated glomerular filtration rate. American Journal of Kidney Diseases 2017 69, 228-236DOI: (10.1053/j.ajkd.2016.08.034) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Adjusted prevalence ratios for frailty status by albumin-creatinine ratio (ACR). Prevalence ratios adjusted for age, sex, race-center, education, smoking status, alcohol consumption, body mass index, systolic blood pressure, anemia (hemoglobin), inflammation (C-reactive protein), cardiovascular disease (history of coronary heart disease, peripheral artery disease, heart failure, and stroke), diabetes, hypertension medications use, statin medication use), and estimated glomerular filtration rate. Abbreviation: CI, confidence interval. American Journal of Kidney Diseases 2017 69, 228-236DOI: (10.1053/j.ajkd.2016.08.034) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

Figure 3 Demographically adjusted prevalence ratios (95% confidence intervals [CIs]) of frailty by (A) creatinine-based estimated glomerular filtration rate (eGFRcr) or (B) cystatin C−based eGFR (eGFRcys) and albuminuria category. ∗P≤0.05; ∗∗P≤0.01; ∗∗∗P≤0.001. American Journal of Kidney Diseases 2017 69, 228-236DOI: (10.1053/j.ajkd.2016.08.034) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions