Ragavendra R. Baliga, MD, MBA  Heart Failure Clinics 

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Editorial: Sudden Death in Heart Failure: An Ounce of Prediction is Worth a Pound of Prevention  Ragavendra R. Baliga, MD, MBA  Heart Failure Clinics  Volume 7, Issue 2, Pages xiii-xviii (April 2011) DOI: 10.1016/j.hfc.2011.02.001 Copyright © 2011 Elsevier Inc. Terms and Conditions

Fig. 1 Severity of heart failure and mode of death. CHF, congestive heart failure. (From Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet 1999;353(9169):2001–7; with permission.) Heart Failure Clinics 2011 7, xiii-xviiiDOI: (10.1016/j.hfc.2011.02.001) Copyright © 2011 Elsevier Inc. Terms and Conditions

Fig. 2 Antiarrhythmic therapy can perform worse than placebo. Inferior performance of antiarrhythmic therapy compared with control group in the SCD-HeFT NYHA functional class III patients (top) and the MUSTT (bottom). CI, confidence interval; EPG, electrophysiology-guided. (From Tung R, Zimetbaum P, Josephson ME. A critical appraisal of implantable cardioverter-defibrillator therapy for the prevention of sudden cardiac death. J Am Coll Cardiol 2008;52(14):1111–21; with permission.) Heart Failure Clinics 2011 7, xiii-xviiiDOI: (10.1016/j.hfc.2011.02.001) Copyright © 2011 Elsevier Inc. Terms and Conditions

Fig. 3 Appropriate shocks outnumber control arrhythmic mortality in 6 of 7 trials. AMIOVIRT, Amiodarone versus Implantable Cardioverter Defibrillator Trial; AVID, Antiarrhythmics versus Implantable Defibrillators trial; DEFINITE, Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation trial; DINAMIT, Defibrillators in Acute Myocardial Infarction Trial. (Adapted from Germano JJ, Reynolds M, Essebag V, et al. Frequency and causes of implantable cardioverter-defibrillator therapies: is device therapy proarrhythmic? Am J Cardiol 2006;97(8):1255–61; with permission; and Tung R, Zimetbaum P, Josephson ME. A critical appraisal of implantable cardioverter-defibrillator therapy for the prevention of sudden cardiac death. J Am Coll Cardiol 2008;52(14):1111–21; with permission.) Heart Failure Clinics 2011 7, xiii-xviiiDOI: (10.1016/j.hfc.2011.02.001) Copyright © 2011 Elsevier Inc. Terms and Conditions

Ragavendra R. Baliga, MD, MBA, Consulting Editor Heart Failure Clinics 2011 7, xiii-xviiiDOI: (10.1016/j.hfc.2011.02.001) Copyright © 2011 Elsevier Inc. Terms and Conditions

James B. Young, MD, Consulting Editor Heart Failure Clinics 2011 7, xiii-xviiiDOI: (10.1016/j.hfc.2011.02.001) Copyright © 2011 Elsevier Inc. Terms and Conditions

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