1. Date of download: 7/6/2016 Copyright © The American College of Cardiology. All rights reserved. From: Hypertrophic Cardiomyopathy in Adulthood Associated With Low Cardiovascular Mortality With Contemporary Management Strategies J Am Coll Cardiol. 2015;65(18):1915-1928. doi:10.1016/j.jacc.2015.02.061 Natural History of HCM in Midlife Adults Summary of clinical outcomes in 1,000 individual HCM patients, 30 to 59 years of age, at study entry. *Appropriate ICD shocks 1.5 years prior to transplant and 6.1 years before death from transplantation complications. †1 patient died despite ICD in place. ‡1 patient with an appropriate ICD shock 20 months prior to death from heart failure. §Includes 1 survivor with CAD, resuscitated cardiac arrest, and myocardial infarction. ‖ Includes 1 patient with resuscitated out-of-hospital cardiac arrest unrelated to HCM 4 years before death. AF = atrial fibrillation; CA = cardiac arrest; CAD = coronary artery disease; CV = cardiovascular; ICD = implantable cardioverter-defibrillator; HCM = hypertrophic cardiomyopathy; HF = heart failure; SCD = sudden cardiac death; VT/VF = ventricular tachycardia/ventricular fibrillation; w/o = without. Figure Legend:

2. Date of download: 7/6/2016 Copyright © The American College of Cardiology. All rights reserved. From: Hypertrophic Cardiomyopathy in Adulthood Associated With Low Cardiovascular Mortality With Contemporary Management Strategies J Am Coll Cardiol. 2015;65(18):1915-1928. doi:10.1016/j.jacc.2015.02.061 HCM Mortality Rates in Midlife Adults Mortality rates per person-year in 1,000 HCM patients initially evaluated at 30 to 59 years of age. *Includes 5 transplant-related deaths. SCD = sudden cardiac death; other abbreviations are as shown in Figure 1. Figure Legend:

3. Date of download: 7/6/2016 Copyright © The American College of Cardiology. All rights reserved. From: Hypertrophic Cardiomyopathy in Adulthood Associated With Low Cardiovascular Mortality With Contemporary Management Strategies J Am Coll Cardiol. 2015;65(18):1915-1928. doi:10.1016/j.jacc.2015.02.061 Decreasing Mortality Due to HCM Historical 50-year reduction in HCM-related mortality to the current rate of 0.5%/year, achieved with contemporary management strategies, and in comparison to the age- and sex-matched general population. HCM = hypertrophic cardiomyopathy; ICD = implantable cardioverter-defibrillator; OHCA = out-of-hospital cardiac arrest. Figure Legend:

4. Date of download: 7/6/2016 Copyright © The American College of Cardiology. All rights reserved. From: Hypertrophic Cardiomyopathy in Adulthood Associated With Low Cardiovascular Mortality With Contemporary Management Strategies J Am Coll Cardiol. 2015;65(18):1915-1928. doi:10.1016/j.jacc.2015.02.061 Survival in Midlife HCM Adults Kaplan-Meier survival curves in 1,000 HCM patients, with relevant comparisons between subgroups and to expected all-cause mortality in the U.S. general population, matched for age and sex. Dotted lines represent 95% confidence intervals for survival probability. (A) All-cause mortality in HCM patients versus general population. (B) HCM-related mortality versus all-cause mortality in the general population. (C) Combined life-threatening HCM events aborted by treatment interventions and HCM-related mortality versus all-cause mortality in the general population. HCM = hypertrophic cardiomyopathy. Figure Legend: