Dysregulation of Wnt/β-catenin and EphB/EphrinB signaling after 56Fe radiation. Dysregulation of Wnt/β-catenin and EphB/EphrinB signaling after 56Fe radiation.

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Dysregulation of Wnt/β-catenin and EphB/EphrinB signaling after 56Fe radiation. Dysregulation of Wnt/β-catenin and EphB/EphrinB signaling after 56Fe radiation. (A) Immunoblots show decreased Wnt antagonist Dkk1, increased phospho-GSK3β, increased activated β-catenin, and increased EphB/EphrinB after 56Fe. (B) Immunofluorescence image showing increased EphB3 after 56Fe radiation. (Scale bars, 5 μm.) (C) Putative TCF/LEF family of transcription factor binding sites on the promoter of the EphrinB1 and EphB3 genes relative to transcription start sites. While four binding sites are on the EphrinB1 promoter, three binding sites are on the EphB3 promoter. Gray boxes, binding sites; numbers, location of the binding-site end positions; colored lines and the numbers above, PCR primer span and the number of primer pairs; red lines, PCR nonamplification; blue lines, successful PCR amplification. (D) Quantitative RT-PCR results from immunoprecipitated DNA show enhanced β-catenin binding to the EphrinB1 promoter after 56Fe radiation. (E) qRT-PCR results showing enhanced β-catenin binding to the EphB3 promoter after 56Fe radiation; *, significant relative to control; **, significant relative to γ-rays. Statistical significance is set at P < 0.05 and error bars represent mean ± SEM. Santosh Kumar et al. PNAS 2018;115:42:E9832-E9841 ©2018 by National Academy of Sciences