EMT: Matter of Life or Death?

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EMT: Matter of Life or Death? Sonal Gupta, Anirban Maitra Cell Volume 164, Issue 5, Pages 840-842 (February 2016) DOI: 10.1016/j.cell.2016.02.024 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 TGFβ-Mediated EMT and Apoptosis (Left) TGFβ causes EMT and apoptosis in SMAD4-positive tumor cells by induction of EMT-associated transcription factors like SNAIL, which causes repression of another transcription factor KLF5. In the absence of KLF5, SOX4 causes transcription of pro-apoptotic genes like Bim and Bmf, leading to apoptosis. (Right) In SMAD4-negative cells, TGFβ signaling mediated through SMAD2/3 induces SOX4 induction, which along with KLF5 transcribes a pro-tumorigenic, epithelial progenitor gene expression program. Cell 2016 164, 840-842DOI: (10.1016/j.cell.2016.02.024) Copyright © 2016 Elsevier Inc. Terms and Conditions