Linking miRNA Regulation to BCR-ABL Expression: The Next Dimension

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Linking miRNA Regulation to BCR-ABL Expression: The Next Dimension Jörg Faber, Richard I. Gregory, Scott A. Armstrong Cancer Cell Volume 13, Issue 6, Pages 467-469 (June 2008) DOI: 10.1016/j.ccr.2008.05.013 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Model of ABL1 and BCR-ABL1 Regulation by miR-203 miR-203 is silenced by both genetic and epigenetic mechanisms in lymphomas expressing high levels of ABL1 and in BCR-ABL1-rearranged leukemias. The loss of MiR-203 leads to elevated expression of its direct targets ABL1 and BCR-ABL1, which enhances cell proliferation. Cancer Cell 2008 13, 467-469DOI: (10.1016/j.ccr.2008.05.013) Copyright © 2008 Elsevier Inc. Terms and Conditions