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When Deletions Gain Functions: Commandeering Epigenetic Mechanisms

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Presentation on theme: "When Deletions Gain Functions: Commandeering Epigenetic Mechanisms"— Presentation transcript:

1 When Deletions Gain Functions: Commandeering Epigenetic Mechanisms
Justin Chen, William A. Weiss  Cancer Cell  Volume 26, Issue 2, Pages (August 2014) DOI: /j.ccr Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 GFI1 and GFI1B Hijack Enhancers via Structural Variation
In medulloblastoma, GFI1B (as shown in A) and GFI1 (as shown in B) normally reside in heterochromatic regions with little to no expression. Structural variation including deletions (A) or interchromosomal translocations (B) can lead to juxtaposition of these genes next to enhancers or super-enhancers (as shown in C), which drive oncogenic expression due to their increased concentrations of bound activators and transcription factors (plotted in green and represented by circles and rectangles). Cancer Cell  , DOI: ( /j.ccr ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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