Genomic Dark Matter Sheds Light on EVI1-Driven Leukemia

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Genomic Dark Matter Sheds Light on EVI1-Driven Leukemia Richard P. Koche, Scott A. Armstrong Cancer Cell Volume 25, Issue 4, Pages 407-408 (April 2014) DOI: 10.1016/j.ccr.2014.03.031 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 A Single Enhancer Rearrangement Deregulates Two Oncogenic Drivers (A) The distal enhancer normally drives GATA2 expression in a myeloid-specific manner. Inversion or translocation of the locus simultaneously results in functional haploinsufficiency of GATA2 and upregulation of EVI1. (B) The enhancer can be deactivated through genome editing or pharmacologic BET inhibition. A novel BAC-linking strategy allowed a faithful recapitulation of the rearrangement and disease in a mouse model. Cancer Cell 2014 25, 407-408DOI: (10.1016/j.ccr.2014.03.031) Copyright © 2014 Elsevier Inc. Terms and Conditions