Perspectives on PARP Inhibitors in Ovarian Cancer Has the Time Come for Individualized Care?
Activity Goals
Epidemiology: Ovarian Cancer
PARP and DNA Repair
BRCA and DNA Repair
Synthetic Lethality Is Associated With Inhibition of PARP in the Presence of BRCA Deficiency
PARP Inhibition in BRCA-like Solid Tumors
Repair Mechanisms and BRCAness
BRCA Testing: When Should it Be Done?
PARP Inhibition: Mechanism of Action
Clinical Outcomes in Patients With BRCA Mutations
PARP Inhibitors in Clinical Trials
Case Study 1
Treatment Options
Anticipated PFS With Standard Treatment
Olaparib as Maintenance Therapy: Study Design
Results of BRCA Testing
Results
ASCO 2014: Cediranib/Olaparib
PFS With Cediranib/Olaparib Superior to Olaparib Alone
PFS Increased With Cediranib/Olaparib Combination
Phase 2: PLD vs Olaparib
Case Study 2
Treatment Approach
Neoadjuvant Chemotherapy (NACT) vs Primary Debulking Surgery (PDS)
Dose-Dense Paclitaxel + Carboplatin vs Conventional Regimen
BRCAness and Response to Chemotherapy
GOG9923
Key Issues for Future Developments of PARP Inhibitors
Abbreviations
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