1. Optimizing Combination Endocrine Therapy in HR-Positive Advanced Breast Cancer

3. Topics of Discussion

32. Abbreviations
AE = adverse event ALT = alanine aminotransferase AML = acute myeloid leukemia AST = aspartate aminotransferase BRCAwt = BRCA wild-type CI = confidence interval CR = complete response DDR = DNA damage repair deficiency FACT-O = Functional Assessment of Cancer Therapy -- Ovarian gBRCA = germline BRCA HRD = hormone recombination deficiency HR = hazard ratio LOH = loss of heterogeneity MDS = myelodysplastic syndrome NR = not reached

33. Abbreviations (cont)
PARP = poly ADP-ribose polymerase PFS = progression-free survival PR = partial response QoL = quality of life sBRCA = somatic BRCA TOI = trial outcome index