by Thomas S. Uldrick, and Richard F. Little

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by Thomas S. Uldrick, and Richard F. Little How I treat classical Hodgkin lymphoma in patients infected with human immunodeficiency virus by Thomas S. Uldrick, and Richard F. Little Blood Volume 125(8):1226-1235 February 19, 2015 ©2015 by American Society of Hematology

Histopathology and immunohistochemistry of HIV-cHL. Histopathology and immunohistochemistry of HIV-cHL. (A) Hematoxylin and eosin staining shows cHL, MC subtype. Immunostaining for (B) CD15, (C) CD30, and (D) EBV latent membrane protein 1 demonstrates Hodgkin Reed-Sternberg cells. (E) CD68 staining showing many (>5%)46 macrophages. (F) Hematoxylin and eosin staining at time of relapse shows cHL, MC subtype. Original magnification ×40. Thomas S. Uldrick, and Richard F. Little Blood 2015;125:1226-1235 ©2015 by American Society of Hematology

18FDG-PET in HIV-cHL. 18FDG-PET in HIV-cHL. (A) Baseline 18FDG-PET. Volumetric image shows bulky intensely hypermetabolic cervical, mediastinal, and axillary lymph nodes and multiple focal bone lesions (representative vertebral lesion, red arrow). (B) Interim 18FDG-PET. At the end of cycle 2, coronal image focuses on a small suspicious lesion in left axilla (red arrow); diffuse bone uptake attributable to pegfilgrastim is also noted. After cycle 6, a biopsy sample of residual abnormalities in the left axilla showed reactive changes and no evidence of cHL. (C) End-of-therapy 18FDG-PET. Volumetric image shows resolution of 18FDG avid nodes. (D) Relapse 18FDG-PET. Volumetric image shows left axillary avid lymph node (red arrow) and other small nodes above the diaphragm. Thomas S. Uldrick, and Richard F. Little Blood 2015;125:1226-1235 ©2015 by American Society of Hematology