9-1-1: HSCs Respond to Emergency Calls

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9-1-1: HSCs Respond to Emergency Calls Robert S. Welner, Paul W. Kincade Cell Stem Cell Volume 14, Issue 4, Pages 415-416 (April 2014) DOI: 10.1016/j.stem.2014.03.010 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Bone Marrow Response Pathways to Pathogens Converge on Interleukin-6 Hematopoietic stem and progenitor cells (HSPCs) were known to be directly and indirectly influenced by infections. We now know that they can make and respond to their own growth and differentiation factors such as IL-6. As another mechanism, activated T cells can produce interferon that causes mesenchymal stem cells (MSCs) to make IL-6. These and other processes promote production of innate effector cells such as monocytes (Mono) and dendritic cells (DC) while lymphopoiesis is inhibited. Meanwhile, hematopoietic stem cells (HSCs) can be driven into cycle and mobilized to other tissues. Cell Stem Cell 2014 14, 415-416DOI: (10.1016/j.stem.2014.03.010) Copyright © 2014 Elsevier Inc. Terms and Conditions