Limbic system.

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Presentation transcript:

Limbic system

Limbic system functions Memory Spatial orientation Multimodal sensory integration Emotion processing Motivation and behavioral selection Self knowledge Default network

Limbic system functions Memory Spatial orientation Hippocampal-dienchphalic-parahippocampal- retrospinal network Multimodal sensory integration Emotion processing Motivation and behavioral selection Self knowledge Default network

Hippocampal-dienchphalic-parahippocampal-retrospinal network Alzheimer's disease Amnesias Korsakoff syndrome

Henry Gustav Molaison (H.M.) Surgical removal of left and right medial temporal lobes (hippocampus, parahippocampal gyrus) Anterograde amnesia

Korsakoff Syndrome Neuronal degeneration in the mammillary body, dorsomedial thalamic n. & hippocampus. Often seen in chronic alcoholics: due to thiamine deficiency. Both short- and long-term memory loss. Confabulation. Wernicke-Korsakoff syndrome: profound memory loss & learning difficulties.

Limbic system functions Multimodal sensory integration Emotion processing Motivation and behavioral selection Temporal-amygdala-orbitofrontal Self knowledge Default network

Temporal-amygdala-orbitofrontal semantic deficits (semantic dementia) language difficulties personality changes and other behavioral symptoms (e.g. aggression, disinhibition) Kluver-bucy syndrome Psychopathy Bipolar affective disorders

Temporal-amygdala-orbitofrontal semantic deficits (semantic dementia) language difficulties personality changes and other behavioral symptoms (e.g. aggression, disinhibition) Kluver-bucy syndrome Psychopathy Bipolar affective disorders

Ablation of the amygdala bilaterally Klüver-Bucy Syndrome Hyperphagia Hyperorality Hypersexuality Hypermetamorphosis Agnosia: visual, tactile & auditory Dementia

Limbic system functions Self knowledge Response selection and action monitoring Default network Dorsomedial Default network

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